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Tdark
SNRNP35
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

Protein Summary
Description
The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350887
  • ENSP00000340774
  • ENSG00000184209
  • ENST00000412157
  • ENSP00000403310
  • ENST00000526639
  • ENSP00000432595

Symbol
  • HM1
  • U1SNRNPBP
  • HM-1
  • U1SNRNPBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
cell type or tissue
0.73
tissue sample
0.65
transcription factor
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.999999443
p_ni:  2.38e-7
p_wrong:  3.19e-7
Score:  0.89
Data Source:  BioPlex,STRINGDB
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.999999007
p_ni:  9.89e-7
p_wrong:  3e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999998741
p_ni:  0.000001259
Score:  0.921
Data Source:  BioPlex,STRINGDB
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.999996837
p_ni:  0.000003163
Score:  0.975
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999983361
p_ni:  0.000002318
p_wrong:  0.000014321
Score:  0.987
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999972994
p_ni:  0.000023277
p_wrong:  0.000003729
Score:  0.993
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999954412
p_ni:  0.000002111
p_wrong:  0.000043477
Data Source:  BioPlex
PDCD7
Tbio
Novelty:  0.15531712
p_int:  0.999466213
p_ni:  0.000533221
p_wrong:  5.66e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
RNPC3
Tbio
Novelty:  0.07154673
p_int:  0.999352897
p_ni:  0.000647101
p_wrong:  2e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
SNRNP48
Tbio
Novelty:  0.16395917
p_int:  0.793351473
p_ni:  0.003352617
p_wrong:  0.203295909
Score:  0.993
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
11
11
94
BMI-adjusted waist-hip ratio
1
12
12
93.5
waist circumference
1
6
6
89.5
BMI-adjusted waist circumference
1
6
6
88.3
high density lipoprotein cholesterol measurement
3
3
5
85.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
11
94
BMI-adjusted waist-hip ratio
12
93.5
waist circumference
6
89.5
BMI-adjusted waist circumference
6
88.3
high density lipoprotein cholesterol measurement
5
85.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U11/U12 subunit 35
VGNC:8560
452345
Macaque
small nuclear ribonucleoprotein U11/U12 subunit 35
702933
Mouse
MGI:1923417
76167
Rat
RGD:1310724
360803
Dog
small nuclear ribonucleoprotein U11/U12 subunit 35
VGNC:46606
477450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U11/U12 subunit 35
Macaque
small nuclear ribonucleoprotein U11/U12 subunit 35
Mouse
Rat
Dog
small nuclear ribonucleoprotein U11/U12 subunit 35
Publication Statistics
PubMed Score 1.25
PubMed score by year
PubTator Score 5.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title