Tbio SNRNP27 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Protein Summary

Description

May play a role in mRNA splicing. This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q8WVK2
• Q15410
• U4/U6.U5 snRNP 27 kDa protein

Gene Name

• SNRNP27

Ensembl ID

• ENST00000244227
• ENSP00000244227
• ENSG00000124380
• ENST00000450162
• ENSP00000395144

Symbol

• 27K
• RY1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.74
transcription factor perturbation	0.74
kinase perturbation	0.66
transcription factor binding site profile	0.65
histone modification site profile	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.03   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.03   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (291)

Explore Interacting Targets

1 – 10 of 291

• See Interactions on String-DB

RECQL

Tbio

Family:  Enzyme

Novelty:  0.00840137

p_int:  0.99999763

p_ni:  0.00000237

Score:  0.17

Data Source:  BioPlex,STRINGDB

PRPF3

Tbio

Novelty:  0.01600014

p_int:  0.999989225

p_ni:  0.000010775

Score:  0.937

Data Source:  BioPlex,STRINGDB

WDR5B

Tdark

Novelty:  1.29746249

p_int:  0.999982181

p_ni:  0.000017819

Data Source:  BioPlex

CARD19

Tbio

Family:  Enzyme

Novelty:  0.18215136

p_int:  0.999979792

p_ni:  0.000017819

p_wrong:  0.000002388

Data Source:  BioPlex

EIF2A

Tbio

Novelty:  0.08652858

p_int:  0.999974843

p_ni:  0.000025156

p_wrong:  1e-9

Data Source:  BioPlex

SBDS

Tbio

Novelty:  0.00818779

p_int:  0.999968115

p_ni:  0.000030647

p_wrong:  0.000001238

Data Source:  BioPlex

LSM3

Tbio

Novelty:  0.05044984

p_int:  0.999942634

p_ni:  0.000057027

p_wrong:  3.4e-7

Score:  0.929

Data Source:  BioPlex,STRINGDB

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.999936076

p_ni:  0.000063924

Score:  0.961

Data Source:  BioPlex,STRINGDB

RBM42

Tdark

Novelty:  0.37655036

p_int:  0.999879163

p_ni:  0.000120835

p_wrong:  2e-9

Score:  0.159

Data Source:  BioPlex,STRINGDB

SNRPGP15

Tdark

p_int:  0.999841763

p_ni:  0.000158237

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
nucleic acid binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	2	3		92.7
atrial fibrillation	EFO_0000275	3	4	0	1.1	87.5
platelet count	EFO_0004309	2	2	2		82.6
red blood cell distribution width	EFO_0005192	3	3	3		64.9
reticulocyte count	EFO_0007986	3	2	3		54.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		92.7
atrial fibrillation	EFO_0000275	0	1.1	87.5
platelet count	EFO_0004309	2		82.6
red blood cell distribution width	EFO_0005192	3		64.9
reticulocyte count	EFO_0007986	3		54.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Direct protein sequencing
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
chronotype measurement
mean platelet volume
platelet count
red blood cell distribution width
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein U4/U6.U5 subunit 27	VGNC:10443	100613517
Macaque	small nuclear ribonucleoprotein U4/U6.U5 subunit 27		708670
Mouse	small nuclear ribonucleoprotein 27 (U4/U6.U5)	MGI:1913868	66618
Rat	germ cell-less, spermatogenesis associated 1 [Source:RGD Symbol;Acc:1359265]
Dog	small nuclear ribonucleoprotein U4/U6.U5 subunit 27	VGNC:54546	474626

Species	Name	OMA	EggNOG	Inparanoid
Chimp	small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Macaque	small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Mouse	small nuclear ribonucleoprotein 27 (U4/U6.U5)
Rat	germ cell-less, spermatogenesis associated 1 [Source:RGD Symbol;Acc:1359265]
Dog	small nuclear ribonucleoprotein U4/U6.U5 subunit 27

Publication Statistics

PubMed Score 57.03

PubMed score by year

Reset Zoom

PubTator Score 16.17

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (11)

Items per page:

10

0 of 0

PMID	Year	Title