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Tbio
SNRNP27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Protein Summary
Description
May play a role in mRNA splicing. This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244227
  • ENSP00000244227
  • ENSG00000124380
  • ENST00000450162
  • ENSP00000395144

Symbol
  • 27K
  • RY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.74
transcription factor perturbation
0.74
kinase perturbation
0.66
transcription factor binding site profile
0.65
histone modification site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.03   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.03   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (291)
RECQL
Tbio
Family:  Enzyme
Novelty:  0.00840137
p_int:  0.99999763
p_ni:  0.00000237
Score:  0.17
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999989225
p_ni:  0.000010775
Score:  0.937
Data Source:  BioPlex,STRINGDB
WDR5B
Tdark
Novelty:  1.29746249
p_int:  0.999982181
p_ni:  0.000017819
Data Source:  BioPlex
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.999979792
p_ni:  0.000017819
p_wrong:  0.000002388
Data Source:  BioPlex
EIF2A
Tbio
Novelty:  0.08652858
p_int:  0.999974843
p_ni:  0.000025156
p_wrong:  1e-9
Data Source:  BioPlex
SBDS
Tbio
Novelty:  0.00818779
p_int:  0.999968115
p_ni:  0.000030647
p_wrong:  0.000001238
Data Source:  BioPlex
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999942634
p_ni:  0.000057027
p_wrong:  3.4e-7
Score:  0.929
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999936076
p_ni:  0.000063924
Score:  0.961
Data Source:  BioPlex,STRINGDB
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.999879163
p_ni:  0.000120835
p_wrong:  2e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999841763
p_ni:  0.000158237
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
92.7
3
4
0
1.1
87.5
platelet count
2
2
2
82.6
red blood cell distribution width
3
3
3
64.9
reticulocyte count
3
2
3
54.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.7
0
1.1
87.5
platelet count
2
82.6
red blood cell distribution width
3
64.9
reticulocyte count
3
54.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
VGNC:10443
100613517
Macaque
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
708670
Mouse
MGI:1913868
66618
Rat
Dog
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
VGNC:54546
474626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Macaque
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Mouse
Rat
Dog
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Publication Statistics
PubMed Score 57.03
PubMed score by year
PubTator Score 16.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title