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Tbio
SNPH
Syntaphilin

Protein Summary
Description
Inhibits SNARE complex formation by absorbing free syntaxin-1. Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381867
  • ENSP00000371291
  • ENSG00000101298
  • ENST00000381873
  • ENSP00000371297
  • ENST00000614659
  • ENSP00000479696

Symbol
  • KIAA0374
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
interacting protein
0.71
cellular component
0.69
microRNA
0.59
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
SYBU
Tbio
Novelty:  0.06029092
p_int:  0.999925599
p_wrong:  0.000074401
Score:  0.47
Data Source:  BioPlex,STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.854
Data Source:  STRINGDB
RHOT1
Tbio
Family:  Enzyme
Novelty:  0.01411527
Score:  0.776
Data Source:  STRINGDB
KCNH3
Tclin
Family:  IC
Novelty:  0.05847445
Score:  0.742
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.716
Data Source:  STRINGDB
VAPA
Tbio
Novelty:  0.00169209
Score:  0.71
Data Source:  STRINGDB
KCNF1
Tclin
Family:  IC
Novelty:  0.00797195
Score:  0.704
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.687
Data Source:  STRINGDB
TRAK2
Tbio
Novelty:  0.04192075
Score:  0.684
Data Source:  STRINGDB
TRAK1
Tbio
Novelty:  0.03561577
Score:  0.679
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
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1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
2
4
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaphilin
VGNC:6264
469858
Macaque
RAD21 cohesin complex component like 1 [Source:HGNC Symbol;Acc:HGNC:16271]
Mouse
MGI:2139270
241727
Rat
RGD:1305867
296267
Dog
syntaphilin
VGNC:46604
485812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaphilin
Macaque
RAD21 cohesin complex component like 1 [Source:HGNC Symbol;Acc:HGNC:16271]
Mouse
Rat
Dog
syntaphilin
Publication Statistics
PubMed Score 97.74
PubMed score by year
PubTator Score 25.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title