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Tdark
SNN
Stannin

Protein Summary
Description
Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329565
  • ENSP00000329287
  • ENSG00000184602
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
PubMedID
0.7
virus perturbation
0.59
microRNA
0.58
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.38   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.38   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
MTDH
Tbio
Novelty:  0.00342872
p_int:  0.999972217
p_ni:  0.000027783
Score:  0.309
Data Source:  BioPlex,STRINGDB
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.998035127
p_ni:  0.001964873
Score:  0.196
Data Source:  BioPlex,STRINGDB
TES
Tbio
Novelty:  0.00052221
p_int:  0.997352366
p_ni:  0.002645344
p_wrong:  0.00000229
Score:  0.243
Data Source:  BioPlex,STRINGDB
C1orf131
Tdark
Novelty:  10.11904762
p_int:  0.944091511
p_ni:  0.048354637
p_wrong:  0.007553852
Score:  0.282
Data Source:  BioPlex,STRINGDB
FST
Tbio
Novelty:  0.00085875
Score:  0.785
Data Source:  STRINGDB
SPIN4
Tchem
Novelty:  0.15502253
Score:  0.733
Data Source:  STRINGDB
TXNDC11
Tbio
Novelty:  0.07135045
Score:  0.681
Data Source:  STRINGDB
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
Score:  0.652
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.646
Data Source:  STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
8
4
4
1.3
94.6
electrocardiography
1
2
69
88
low density lipoprotein cholesterol measurement
5
1
5
83.2
sex hormone-binding globulin measurement
4
2
4
82.9
alkaline phosphatase measurement
2
1
1
5.7
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
4
1.3
94.6
electrocardiography
69
88
low density lipoprotein cholesterol measurement
5
83.2
sex hormone-binding globulin measurement
4
82.9
alkaline phosphatase measurement
1
5.7
78.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stannin
VGNC:13788
100608593
Macaque
stannin
711909
Mouse
MGI:1276549
20621
Rat
RGD:3730
29140
Dog
stannin
VGNC:46603
609847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stannin
Macaque
stannin
Mouse
Rat
Dog
stannin
Publication Statistics
PubMed Score 63.38
PubMed score by year
PubTator Score 17.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title