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Tbio
SNF8
Vacuolar-sorting protein SNF8

Protein Summary
Description
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290330
  • ENSP00000290330
  • ENSG00000159210
  • ENST00000502492
  • ENSP00000421380

Symbol
  • EAP30
  • Dot3
  • EAP30
  • VPS22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
histone modification site profile
0.88
interacting protein
0.86
cellular component
0.81
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.06   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.06   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
VPS36
Tbio
Novelty:  0.03382542
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS25
Tbio
Novelty:  0.03002488
p_int:  0.999999977
p_ni:  1.4e-8
p_wrong:  9e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CHMP6
Tbio
Novelty:  0.02931
Score:  0.997
Data Source:  STRINGDB
VPS28
Tbio
Novelty:  0.02927315
Score:  0.995
Data Source:  Reactome,STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.991
Data Source:  STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.989
Data Source:  Reactome,STRINGDB
CHMP3
Tbio
Novelty:  0.01958573
Score:  0.986
Data Source:  STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.984
Data Source:  STRINGDB
CHMP4A
Tbio
Novelty:  0.01163844
Score:  0.984
Data Source:  STRINGDB
HGS
Tbio
Family:  Enzyme
Novelty:  0.00665044
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Endosomal Sorting Complex Required For Transport (ESCRT) (R-HSA-917729)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Endosomal Sorting Complex Required For Transport (ESCRT)
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
3
1.1
94.4
body height
3
3
3
83.6
alkaline phosphatase measurement
2
2
2
6.6
80
body mass index
1
1
1
75.1
odontogenesis
1
1
1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
94.4
body height
3
83.6
alkaline phosphatase measurement
2
6.6
80
body mass index
1
75.1
odontogenesis
1
65.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SNF8, ESCRT-II complex subunit
700029
Mouse
MGI:1343161
27681
Rat
RGD:1310144
287645
Dog
SNF8, ESCRT-II complex subunit
VGNC:46601
491063
Horse
SNF8, ESCRT-II complex subunit
VGNC:23386
100055830
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SNF8, ESCRT-II complex subunit
Mouse
Rat
Dog
SNF8, ESCRT-II complex subunit
Horse
SNF8, ESCRT-II complex subunit
Publication Statistics
PubMed Score 22.06
PubMed score by year
PubTator Score 15.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title