Tbio SND1 Staphylococcal nuclease domain-containing protein 1

Protein Summary

Description

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q7KZF4
• Q13122
• Q96AG0

Gene Name

• SND1

Ensembl ID

• ENST00000354725
• ENSP00000346762
• ENSG00000197157

Symbol

• TDRD11
• p100
• TDRD11
• Tudor-SN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor binding site profile	0.91
virus perturbation	0.88
disease perturbation	0.83
histone modification site profile	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Staphylococcal Nuclease Domain-containing Protein 1

Protein / Nucleic Acid Binding / Staphylococcal Nuclease Domain-containing Protein 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Staphylococcal Nuclease Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.49   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 250   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.49   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0