Protein Summary
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- ENST00000310112
- ENSP00000308057
- ENSG00000074317
- ENST00000393693
- ENSP00000377296
- ENST00000506696
- ENSP00000422223
- ENST00000510387
- ENSP00000424073
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.74 | ||
cellular component | 0.69 | ||
kinase | 0.67 | ||
cell type or tissue | 0.65 | ||
histone modification site profile | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.34 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 346 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.34 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 346 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (188)
NUFIP1
Novelty: 0.11726869
p_int: 0.997939094
p_ni: 0.000364018
p_wrong: 0.001696888
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.997939094
p_ni: 0.000364018
p_wrong: 0.001696888
Data Source: BioPlex
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.997924975
p_ni: 0.000333936
p_wrong: 0.001741089
Data Source: BioPlex
ARMC1
Novelty: 0.02018109
p_int: 0.983720956
p_ni: 0.014839848
p_wrong: 0.001439196
Score: 0.19
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | MTF1 activates gene expression | ||||
Reactome | Response to metal ions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
MTF1 activates gene expression | ||||
Response to metal ions | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
age at menopause | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
age at menopause | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | synuclein beta | VGNC:4168 | 736255 | |||||
Macaque | synuclein beta | 697484 | ||||||
Mouse | MGI:1889011 | 104069 | ||||||
Rat | RGD:70992 | 113893 | ||||||
Dog | synuclein beta | VGNC:46598 | 479279 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | synuclein beta | |||||
Macaque | synuclein beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | synuclein beta | |||||
Publication Statistics
PubMed Score 115.34
PubMed score by year
PubTator Score 76.58
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (38)
Items per page:
0 of 0
PMID | Year | Title |
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