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Tbio
SNCB
Beta-synuclein

Protein Summary
Description
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310112
  • ENSP00000308057
  • ENSG00000074317
  • ENST00000393693
  • ENSP00000377296
  • ENST00000506696
  • ENSP00000422223
  • ENST00000510387
  • ENSP00000424073
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
cellular component
0.69
kinase
0.67
cell type or tissue
0.65
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.34   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.34   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.997939094
p_ni:  0.000364018
p_wrong:  0.001696888
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.997939094
p_ni:  0.000364018
p_wrong:  0.001696888
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.997924975
p_ni:  0.000333936
p_wrong:  0.001741089
Data Source:  BioPlex
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.983720956
p_ni:  0.014839848
p_wrong:  0.001439196
Score:  0.19
Data Source:  BioPlex,STRINGDB
MTF1
Tbio
Family:  TF
Novelty:  0.01350821
Score:  0.9
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.727
Data Source:  STRINGDB
UNC5A
Tbio
Novelty:  0.03749855
Score:  0.698
Data Source:  STRINGDB
TMEM263
Tdark
Novelty:  0.64480022
Score:  0.687
Data Source:  STRINGDB
TSACC
Tbio
Novelty:  0.62833606
Score:  0.684
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
MTF1 activates gene expression
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
MTF1 activates gene expression
Response to metal ions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
49.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synuclein beta
VGNC:4168
736255
Macaque
synuclein beta
697484
Mouse
MGI:1889011
104069
Rat
RGD:70992
113893
Dog
synuclein beta
VGNC:46598
479279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synuclein beta
Macaque
synuclein beta
Mouse
Rat
Dog
synuclein beta
Publication Statistics
PubMed Score 115.34
PubMed score by year
PubTator Score 76.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title