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Tbio
SNCAIP
Synphilin-1

Protein Summary
Description
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261367
  • ENSP00000261367
  • ENSG00000064692
  • ENST00000261368
  • ENSP00000261368
  • ENST00000379538
  • ENSP00000368854
  • ENST00000395469
  • ENSP00000378852

Symbol
  • Sph1
  • SYPH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.78
histone modification site profile
0.75
gene perturbation
0.66
cell type or tissue
0.65
tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.58   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.58   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
TTC28
Tdark
Novelty:  0.16651519
p_int:  0.999848461
p_ni:  0.000151524
p_wrong:  1.5e-8
Data Source:  BioPlex
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999779643
p_ni:  0.000219543
p_wrong:  8.14e-7
Data Source:  BioPlex
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.99969471
p_ni:  0.000033577
p_wrong:  0.000271713
Data Source:  BioPlex
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.857539056
p_ni:  4e-9
p_wrong:  0.14246094
Score:  0.463
Data Source:  BioPlex,STRINGDB
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.796421869
p_ni:  0.203538894
p_wrong:  0.000039238
Score:  0.187
Data Source:  BioPlex,STRINGDB
SNCA
Tchem
Novelty:  0.00012042
Score:  0.996
Data Source:  Reactome,STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.985
Data Source:  Reactome,STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
Score:  0.972
Data Source:  Reactome,STRINGDB
SIAH2
Tbio
Family:  Enzyme
Novelty:  0.01461174
Score:  0.961
Data Source:  Reactome,STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.846
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
4
3
8
90.5
1
1
0
9
52.6
maximal oxygen uptake measurement
2
1
2
27.8
cortical thickness
1
1
0
12.8
22.5
hemoglobin measurement
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to exercise
8
90.5
0
9
52.6
maximal oxygen uptake measurement
2
27.8
cortical thickness
0
12.8
22.5
hemoglobin measurement
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synuclein alpha interacting protein
VGNC:13595
462021
Macaque
synuclein alpha interacting protein
700372
Mouse
MGI:1915097
67847
Rat
RGD:1309283
307309
Dog
synuclein alpha interacting protein
VGNC:46597
481479
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synuclein alpha interacting protein
Macaque
synuclein alpha interacting protein
Mouse
Rat
Dog
synuclein alpha interacting protein
Publication Statistics
PubMed Score 118.58
PubMed score by year
PubTator Score 66.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title