Protein Summary
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- ENST00000336904
- ENSP00000338345
- ENSG00000145335
- ENST00000345009
- ENSP00000343683
- ENST00000394986
- ENSP00000378437
- ENST00000394989
- ENSP00000378440
- ENST00000394991
- ENSP00000378442
- ENST00000420646
- ENSP00000396241
- ENST00000505199
- ENSP00000421485
- ENST00000506244
- ENSP00000422238
- ENST00000508895
- ENSP00000426955
- ENST00000618500
- ENSP00000484044
- NACP
- PARK1
- PD1
- NACP
- PARK1
- PARK4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
molecular function | 1 | ||
biological term | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9137.04 (req: < 5)
Gene RIFs: 1403 (req: <= 3)
Antibodies: 2667 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9137.04 (req: >= 5)
Gene RIFs: 1403 (req: > 3)
Antibodies: 2667 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 99
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 177
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (177)
Protein-Protein Interactions (305)
MAN2C1
Family: Enzyme
Novelty: 0.01159051
p_int: 0.999995048
p_ni: 0.000004908
p_wrong: 4.4e-8
Score: 0.354
Data Source: BioPlex,STRINGDB
TMPRSS12
Family: Enzyme
Novelty: 0.38051198
p_int: 0.997573342
p_ni: 0.002426658
Score: 0.208
Data Source: BioPlex,STRINGDB
HK1
Family: Kinase
Novelty: 0.00195554
p_int: 0.992731345
p_ni: 0.007268655
Score: 0.254
Data Source: BioPlex,STRINGDB
DNAAF2
Novelty: 0.01254416
p_int: 0.945120326
p_ni: 0.054879649
p_wrong: 2.5e-8
Data Source: BioPlex
HCLS1
Novelty: 0.08304056
p_int: 0.915728689
p_ni: 0.006128783
p_wrong: 0.078142528
Score: 0.269
Data Source: BioPlex,STRINGDB
SERPINB13
Novelty: 0.01753451
p_int: 0.882892549
p_ni: 0.117106916
p_wrong: 5.35e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (2)
KEGG (2)
PathwayCommons (3)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (128)
Functions (24)
Components (29)
Processes (75)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
16 | 8 | 1 | 1.3 | 99.3 | |||||
insomnia measurement | 1 | 2 | 0 | 1.1 | 66.6 | ||||
1 | 1 | 0 | 1.4 | 56 | |||||
neuroticism measurement | 2 | 2 | 0 | 6.2 | 55.8 | ||||
age at onset | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
1 | 1.3 | 99.3 | |||||
insomnia measurement | 0 | 1.1 | 66.6 | ||||
0 | 1.4 | 56 | |||||
neuroticism measurement | 0 | 6.2 | 55.8 | ||||
age at onset | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | synuclein alpha | 706985 | ||||||
Mouse | MGI:1277151 | 20617 | ||||||
Rat | RGD:3729 | 29219 | ||||||
Dog | synuclein alpha | VGNC:46596 | 478478 | |||||
Horse | synuclein alpha | VGNC:23382 | 100053270 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | synuclein alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | synuclein alpha | |||||
Horse | synuclein alpha | |||||
Publication Statistics
PubMed Score 9137.04
PubMed score by year
PubTator Score 4467.47
PubTator score by year
Related Publications
Text Mined References (1503)
GeneRif Annotations (1403)
Items per page:
0 of 0
PMID | Year | Title |
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