Tchem SNCA Alpha-synuclein

Protein Summary

Description

May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P37840
• A8K2A4
• Q13701
• Q4JHI3
• Q6IAU6

Gene Name

• SNCA

Ensembl ID

• ENST00000336904
• ENSP00000338345
• ENSG00000145335
• ENST00000345009
• ENSP00000343683
• ENST00000394986
• ENSP00000378437
• ENST00000394989
• ENSP00000378440
• ENST00000394991
• ENSP00000378442
• ENST00000420646
• ENSP00000396241
• ENST00000505199
• ENSP00000421485
• ENST00000506244
• ENSP00000422238
• ENST00000508895
• ENSP00000426955
• ENST00000618500
• ENSP00000484044

Symbol

• NACP
• PARK1
• PD1
• NACP
• PARK1
• PARK4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
kinase	1
molecular function	1
biological term	0.99

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Alpha-synuclein

Protein / Chaperone / Alpha-synuclein

DTO Classes

Protein / Transporter / Alpha-synuclein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9137.04   (req: < 5)

Gene RIFs: 1403   (req: <= 3)

Antibodies: 2667   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9137.04   (req: >= 5)

Gene RIFs: 1403   (req: > 3)

Antibodies: 2667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 99

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 177

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (177)

Explore Active Ligands

1 – 10 of 177

CHEMBL3593904

SNCATchem

pKi : 7.46

3-(3-(4-(Dimethylamino)phenyl)allylidene)indolin-2-one

SNCATchem

pKi : 7.27

CHEMBL3593922

SNCATchem

pKi : 7.57

CHEMBL3593905

SNCATchem

pKi : 7.32

CHEMBL3593893

SNCATchem

pKi : 6.72

CHEMBL3593912

SNCATchem

pKi : 6.73

3-(3-(4-Aminophenyl)allylidene)indolin-2-one

SNCATchem

pKi : 7.42

CHEMBL3593908

SNCATchem

pKi : 6.64

CHEMBL3593923

SNCATchem

pKi : 6.68

CHEMBL3593930

SNCATchem

pKi : 6.82

Protein-Protein Interactions (305)

Explore Interacting Targets

1 – 10 of 305

• See Interactions on String-DB

MAN2C1

Tbio

Family:  Enzyme

Novelty:  0.01159051

p_int:  0.999995048

p_ni:  0.000004908

p_wrong:  4.4e-8

Score:  0.354

Data Source:  BioPlex,STRINGDB

TMPRSS12

Tdark

Family:  Enzyme

Novelty:  0.38051198

p_int:  0.997573342

p_ni:  0.002426658

Score:  0.208

Data Source:  BioPlex,STRINGDB

HK1

Tchem

Family:  Kinase

Novelty:  0.00195554

p_int:  0.992731345

p_ni:  0.007268655

Score:  0.254

Data Source:  BioPlex,STRINGDB

DNAAF2

Tbio

Novelty:  0.01254416

p_int:  0.945120326

p_ni:  0.054879649

p_wrong:  2.5e-8

Data Source:  BioPlex

HCLS1

Tbio

Novelty:  0.08304056

p_int:  0.915728689

p_ni:  0.006128783

p_wrong:  0.078142528

Score:  0.269

Data Source:  BioPlex,STRINGDB

SERPINB13

Tbio

Novelty:  0.01753451

p_int:  0.882892549

p_ni:  0.117106916

p_wrong:  5.35e-7

Score:  0.165

Data Source:  BioPlex,STRINGDB

SNCAIP

Tbio

Novelty:  0.01355161

Score:  0.996

Data Source:  Reactome,STRINGDB

PRKN

Tbio

Family:  Enzyme

Novelty:  0.00079898

Score:  0.992

Data Source:  STRINGDB

PARK7

Tbio

Family:  Enzyme

Novelty:  0.00104651

Score:  0.99

Data Source:  STRINGDB

APP

Tchem

Novelty:  0.00008964

Score:  0.985

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (2)

KEGG (2)

PathwayCommons (3)

WikiPathways (4)

Amyloid fiber formation (R-HSA-977225)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Amyloid fiber formation	79 targets	R-HSA-977225
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (128)

Functions (24)

Components (29)

Processes (75)

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1 – 10 of 24

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
copper ion binding	Inferred from Direct Assay (IDA)	UniProtKB
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Inferred from Direct Assay (IDA)	UniProtKB
ferrous iron binding	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
oxidoreductase activity	Inferred from Direct Assay (IDA)	UniProtKB
phospholipid binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
phosphoprotein binding	Inferred from Direct Assay (IDA)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (8)

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1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	16	8	1	1.3	99.3
insomnia measurement	EFO_0007876	1	2	0	1.1	66.6
Lewy body dementia	EFO_0006792	1	1	0	1.4	56
neuroticism measurement	EFO_0007660	2	2	0	6.2	55.8
age at onset	EFO_0004847	1	1	1		54.4

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	1	1.3	99.3
insomnia measurement	EFO_0007876	0	1.1	66.6
Lewy body dementia	EFO_0006792	0	1.4	56
neuroticism measurement	EFO_0007660	0	6.2	55.8
age at onset	EFO_0004847	1		54.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Alzheimer disease
Amyloid
Cell junction
Complete proteome
Copper
Cytoplasm
Direct protein sequencing

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
anxiety measurement
feeling nervous measurement
insomnia measurement
Lewy body dementia
neuroticism measurement
Parkinson's disease
worry measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
muscle phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	synuclein alpha		706985
Mouse	synuclein, alpha	MGI:1277151	20617
Rat	synuclein alpha	RGD:3729	29219
Dog	synuclein alpha	VGNC:46596	478478
Horse	synuclein alpha	VGNC:23382	100053270

Species	Name	OMA	EggNOG	Inparanoid
Macaque	synuclein alpha
Mouse	synuclein, alpha
Rat	synuclein alpha
Dog	synuclein alpha
Horse	synuclein alpha

Publication Statistics

PubMed Score 9137.04

PubMed score by year

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PubTator Score 4467.47

PubTator score by year

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Related Publications

Text Mined References (1503)

GeneRif Annotations (1403)

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PMID	Year	Title