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Tchem
SNCA
Alpha-synuclein

Protein Summary
Description
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336904
  • ENSP00000338345
  • ENSG00000145335
  • ENST00000345009
  • ENSP00000343683
  • ENST00000394986
  • ENSP00000378437
  • ENST00000394989
  • ENSP00000378440
  • ENST00000394991
  • ENSP00000378442
  • ENST00000420646
  • ENSP00000396241
  • ENST00000505199
  • ENSP00000421485
  • ENST00000506244
  • ENSP00000422238
  • ENST00000508895
  • ENSP00000426955
  • ENST00000618500
  • ENSP00000484044

Symbol
  • NACP
  • PARK1
  • PD1
  • NACP
  • PARK1
  • PARK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
1
molecular function
1
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10610.64   (req: < 5)
Gene RIFs: 1403   (req: <= 3)
Antibodies: 2667   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10610.64   (req: >= 5)
Gene RIFs: 1403   (req: > 3)
Antibodies: 2667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 99
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 187
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7