You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SNAPC4
snRNA-activating protein complex subunit 4

Protein Summary
Description
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298532
  • ENSP00000298532
  • ENSG00000165684

Symbol
  • SNAP190
  • SNAP190
  • PTFalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.74
cell type or tissue
0.7
tissue sample
0.62
kinase perturbation
0.6
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
SNAPC1
Tbio
Novelty:  0.18444701
p_int:  0.999999992
p_ni:  3e-9
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999999109
p_ni:  8.91e-7
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999998374
p_ni:  0.000001619
p_wrong:  7e-9
Score:  0.671
Data Source:  BioPlex,STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.999791239
p_ni:  0.000208755
p_wrong:  6e-9
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.998648006
p_ni:  0.001351993
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TCEAL9
Tdark
Novelty:  0.3050647
p_int:  0.933602565
p_ni:  0.0663967
p_wrong:  7.36e-7
Data Source:  BioPlex
SNAPC3
Tbio
Novelty:  0.11748003
Score:  0.995
Data Source:  STRINGDB
SNAPC2
Tdark
Novelty:  0.26291137
Score:  0.993
Data Source:  STRINGDB
SNAPC5
Tdark
Novelty:  0.61681654
Score:  0.989
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
10
4
1.1
98.8
3
3
1
1.2
94.9
HbA1c measurement
3
3
3
94.5
leukocyte count
3
3
3
92.1
4
3
1
1.1
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.8
1
1.2
94.9
HbA1c measurement
3
94.5
leukocyte count
3
92.1
1
1.1
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear RNA activating complex polypeptide 4
VGNC:13966
464918
Macaque
small nuclear RNA activating complex polypeptide 4
721758
Mouse
MGI:2443935
227644
Rat
RGD:1309048
362088
Dog
small nuclear RNA activating complex polypeptide 4
VGNC:46593
491251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear RNA activating complex polypeptide 4
Macaque
small nuclear RNA activating complex polypeptide 4
Mouse
Rat
Dog
small nuclear RNA activating complex polypeptide 4
Publication Statistics
PubMed Score 11.91
PubMed score by year
PubTator Score 8.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title