Tbio SNAP91 Clathrin coat assembly protein AP180

Protein Summary

Description

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).

Uniprot Accession IDs

• O60641
• A8K0L7
• E5RI02
• Q5JX13
• Q68DL9
• Q6P9D3
• Q9NTY7

Gene Name

• SNAP91

Ensembl ID

• ENST00000369694
• ENSP00000358708
• ENSG00000065609
• ENST00000439399
• ENSP00000400459
• ENST00000520213
• ENSP00000428026
• ENST00000520302
• ENSP00000428511
• ENST00000521743
• ENSP00000428215

Symbol

• KIAA0656
• CALM
• AP180

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
PubMedID	0.68
cellular component	0.64
tissue sample	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Clathrin Coat Assembly Protein Ap180

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Clathrin Coat Assembly Protein Ap180

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.62   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.62   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0