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Tbio
SNAP91
Clathrin coat assembly protein AP180

Protein Summary
Description
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369694
  • ENSP00000358708
  • ENSG00000065609
  • ENST00000439399
  • ENSP00000400459
  • ENST00000520213
  • ENSP00000428026
  • ENST00000520302
  • ENSP00000428511
  • ENST00000521743
  • ENSP00000428215

Symbol
  • KIAA0656
  • CALM
  • AP180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
PubMedID
0.68
cellular component
0.64
tissue sample
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.22   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.22   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (254)
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999674161
p_ni:  0.000325836
p_wrong:  3e-9
Data Source:  BioPlex
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.99956569
p_ni:  0.00043431
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.996634954
p_ni:  0.003365045
p_wrong:  2e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.984951828
p_ni:  0.015048171
p_wrong:  1e-9
Data Source:  BioPlex
CDCA8
Tbio
Novelty:  0.01448513
p_int:  0.854252655
p_ni:  0.145410482
p_wrong:  0.000336864
Score:  0.189
Data Source:  BioPlex,STRINGDB
HIP1R
Tbio
Novelty:  0.02502713
Score:  0.994
Data Source:  STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.994
Data Source:  STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.993
Data Source:  STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.979
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
2
1.1
79.1
refractive error measurement
1
1
1
60.2
ganglion cell inner plexiform layer thickness measurement
1
1
1
35
intelligence
1
1
1
27.3
self reported educational attainment
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
79.1
refractive error measurement
1
60.2
ganglion cell inner plexiform layer thickness measurement
1
35
intelligence
1
27.3
self reported educational attainment
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synaptosome associated protein 91
695216
Mouse
MGI:109132
20616
Rat
RGD:69276
65178
Dog
synaptosome associated protein 91
VGNC:46590
403452
Horse
synaptosome associated protein 91
VGNC:23377
100065464
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synaptosome associated protein 91
Mouse
Rat
Dog
synaptosome associated protein 91
Horse
synaptosome associated protein 91
Publication Statistics
PubMed Score 115.22
PubMed score by year
PubTator Score 248.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title