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Tclin
SNAP25
Synaptosomal-associated protein 25

Protein Summary
Description
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254976
  • ENSP00000254976
  • ENSG00000132639
  • ENST00000304886
  • ENSP00000307341

Symbol
  • SNAP
  • SUP
  • RIC4
  • SEC9
  • SNAP
  • CMS18
  • RIC-4
  • SNAP-25
  • bA416N4.2
  • dJ1068F16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
phenotype
0.9
cellular component
0.88
biological process
0.79
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.09   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 1092   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.09   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 1092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (542)
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999993955
p_ni:  0.000003609
p_wrong:  0.000002436
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999988204
p_ni:  0.000011592
p_wrong:  2.03e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.993937016
p_ni:  0.000012327
p_wrong:  0.006050658
Score:  0.183
Data Source:  BioPlex,STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.999
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.999
Data Source:  Reactome,STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.999
Data Source:  Reactome,STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.998
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.998
Data Source:  STRINGDB
STX1B
Tbio
Novelty:  0.01171833
Score:  0.996
Data Source:  STRINGDB
RPH3A
Tbio
Family:  Epigenetic
Novelty:  0.01321524
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (56)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
GABA synthesis, release, reuptake and degradation
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Cytokine Signaling in Immune system
Disease
Dopamine Neurotransmitter Release Cycle
GABA synthesis, release, reuptake and degradation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptosome associated protein 25
VGNC:6263
458096
Macaque
synaptosome associated protein 25
574204
Mouse
MGI:98331
20614
Dog
synaptosome associated protein 25
VGNC:46588
477158
Horse
synaptosome associated protein 25
VGNC:23374
100051273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptosome associated protein 25
Macaque
synaptosome associated protein 25
Mouse
Dog
synaptosome associated protein 25
Horse
synaptosome associated protein 25
Publication Statistics
PubMed Score 654.09
PubMed score by year
PubTator Score 772.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title