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Tbio
SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

Protein Summary
Description
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243112
  • ENSP00000243112
  • ENSG00000123415
  • ENST00000337581
  • ENSP00000338606
  • ENST00000401977
  • ENSP00000384828
  • ENST00000506595
  • ENSP00000421206
  • ENST00000508394
  • ENSP00000424191
  • ENST00000513838
  • ENSP00000423629
  • ENST00000514685
  • ENSP00000421139

Symbol
  • FDG
  • UNG3
  • HMUDG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.84
histone modification site profile
0.73
transcription factor binding site profile
0.71
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.94   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.94   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.95
Data Source:  Reactome,STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.877
Data Source:  STRINGDB
TDG
Tbio
Family:  Enzyme
Novelty:  0.00283178
Score:  0.857
Data Source:  STRINGDB
UNG
Tbio
Family:  Enzyme
Novelty:  0.00268354
Score:  0.836
Data Source:  STRINGDB
SLC2A1
Tchem
Family:  Transporter
Novelty:  0.00027583
Score:  0.831
Data Source:  STRINGDB
MBD4
Tbio
Family:  TF
Novelty:  0.00876432
Score:  0.8
Data Source:  STRINGDB
FLT1
Tclin
Family:  Kinase
Novelty:  0.00039648
Score:  0.789
Data Source:  STRINGDB
CEACAM5
Tbio
Novelty:  0.00007291
Score:  0.77
Data Source:  STRINGDB
TG
Tbio
Novelty:  0.00010111
Score:  0.764
Data Source:  STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
Score:  0.748
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (44)
Base Excision Repair (R-HSA-73884)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Reactome
Depyrimidination
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Depyrimidination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
7
17
97.7
waist-hip ratio
4
6
7
96.9
waist circumference
2
4
4
92.3
BMI-adjusted waist circumference
7
6
17
91.9
5
3
4
1.1
87.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
17
97.7
waist-hip ratio
7
96.9
waist circumference
4
92.3
BMI-adjusted waist circumference
17
91.9
4
1.1
87.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
single-strand-selective monofunctional uracil-DNA glycosylase 1
VGNC:8558
451953
Macaque
single-strand-selective monofunctional uracil-DNA glycosylase 1
704743
Mouse
MGI:1918976
71726
Rat
RGD:631403
315344
Dog
single-strand-selective monofunctional uracil-DNA glycosylase 1
VGNC:46579
486497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
single-strand-selective monofunctional uracil-DNA glycosylase 1
Macaque
single-strand-selective monofunctional uracil-DNA glycosylase 1
Mouse
Rat
Dog
single-strand-selective monofunctional uracil-DNA glycosylase 1
Publication Statistics
PubMed Score 75.94
PubMed score by year
PubTator Score 143.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title