You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

Protein Summary
Description
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243112
  • ENSP00000243112
  • ENSG00000123415
  • ENST00000337581
  • ENSP00000338606
  • ENST00000401977
  • ENSP00000384828
  • ENST00000506595
  • ENSP00000421206
  • ENST00000508394
  • ENSP00000424191
  • ENST00000513838
  • ENSP00000423629
  • ENST00000514685
  • ENSP00000421139

Symbol
  • FDG
  • UNG3
  • HMUDG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.84
histone modification site profile
0.73
transcription factor binding site profile
0.71
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.49   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.49   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0