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Tbio
SMPDL3B
Acid sphingomyelinase-like phosphodiesterase 3b

Protein Summary
Description
Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373888
  • ENSP00000362995
  • ENSG00000130768
  • ENST00000373894
  • ENSP00000363001

Symbol
  • ASML3B
  • ASMLPD
  • ASML3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
gene perturbation
0.76
small molecule perturbation
0.61
tissue sample
0.61
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0