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Tbio
SMPDL3B
Acid sphingomyelinase-like phosphodiesterase 3b

Protein Summary
Description
Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373888
  • ENSP00000362995
  • ENSG00000130768
  • ENST00000373894
  • ENSP00000363001

Symbol
  • ASML3B
  • ASMLPD
  • ASML3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
gene perturbation
0.76
small molecule perturbation
0.61
tissue sample
0.61
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.41   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.41   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
HFE
Tbio
Novelty:  0.00042077
p_int:  0.999994752
p_ni:  0.000005211
p_wrong:  3.7e-8
Data Source:  BioPlex
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.875064465
p_ni:  0.124935535
Score:  0.182
Data Source:  BioPlex,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.799369627
p_ni:  0.200630373
Score:  0.248
Data Source:  BioPlex,STRINGDB
CMBL
Tbio
Family:  Enzyme
Novelty:  0.00579339
Score:  0.618
Data Source:  STRINGDB
UNC45A
Tbio
Novelty:  0.07503761
Score:  0.617
Data Source:  STRINGDB
UPP1
Tchem
Family:  Enzyme
Novelty:  0.01384975
Score:  0.571
Data Source:  STRINGDB
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
Score:  0.555
Data Source:  STRINGDB
PRUNE1
Tchem
Novelty:  0.02136836
Score:  0.554
Data Source:  STRINGDB
BRINP1
Tbio
Novelty:  0.0530291
Score:  0.551
Data Source:  STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
Score:  0.543
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
87.8
1
1
0
1.6
76.5
myeloid white cell count
2
2
2
76
monocyte count
1
1
1
68.8
leukocyte count
2
2
2
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
87.8
0
1.6
76.5
myeloid white cell count
2
76
monocyte count
1
68.8
leukocyte count
2
65.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase acid like 3B
VGNC:6997
456681
Mouse
MGI:1916022
100340
Rat
RGD:1307458
362619
Dog
sphingomyelin phosphodiesterase acid like 3B
VGNC:46574
100855784
Horse
sphingomyelin phosphodiesterase acid like 3B
VGNC:23358
100070816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase acid like 3B
Mouse
Rat
Dog
sphingomyelin phosphodiesterase acid like 3B
Horse
sphingomyelin phosphodiesterase acid like 3B
Publication Statistics
PubMed Score 21.41
PubMed score by year
PubTator Score 5.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title