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Tbio
SMPDL3A
Acid sphingomyelinase-like phosphodiesterase 3a

Protein Summary
Description
Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368440
  • ENSP00000357425
  • ENSG00000172594
  • ENST00000539041
  • ENSP00000442152

Symbol
  • ASML3A
  • ASM3A
  • ASML3a
  • yR36GH4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
disease perturbation
0.93
transcription factor perturbation
0.88
PubMedID
0.85
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.18   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.18   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
BRINP1
Tbio
Novelty:  0.0530291
Score:  0.99
Data Source:  STRINGDB
PRF1
Tchem
Novelty:  0.0002835
Score:  0.713
Data Source:  STRINGDB
TTC23
Tdark
Novelty:  0.88342635
Score:  0.713
Data Source:  STRINGDB
CMBL
Tbio
Family:  Enzyme
Novelty:  0.00579339
Score:  0.663
Data Source:  STRINGDB
APTX
Tbio
Novelty:  0.00812241
Score:  0.577
Data Source:  STRINGDB
TATDN2
Tdark
Family:  Enzyme
Novelty:  1.40236433
Score:  0.577
Data Source:  STRINGDB
SHISAL1
Tdark
Novelty:  0.66511357
Score:  0.57
Data Source:  STRINGDB
PRUNE1
Tchem
Novelty:  0.02136836
Score:  0.554
Data Source:  STRINGDB
ACP7
Tdark
Family:  Enzyme
Novelty:  0.05718825
Score:  0.545
Data Source:  STRINGDB
VPS39
Tbio
Novelty:  0.02172601
Score:  0.501
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
87.5
acid sphingomyelinase-like phosphodiesterase 3a measurement
1
1
1
71.9
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
87.5
acid sphingomyelinase-like phosphodiesterase 3a measurement
1
71.9
1
7.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase acid like 3A
VGNC:7930
462976
Macaque
sphingomyelin phosphodiesterase acid like 3A
713696
Mouse
MGI:1931437
57319
Rat
RGD:1359277
294422
Dog
sphingomyelin phosphodiesterase acid like 3A
VGNC:46573
476279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase acid like 3A
Macaque
sphingomyelin phosphodiesterase acid like 3A
Mouse
Rat
Dog
sphingomyelin phosphodiesterase acid like 3A
Publication Statistics
PubMed Score 9.18
PubMed score by year
PubTator Score 3.92
PubTator score by year
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Related Publications
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PMID
Year
Title