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Tchem
SMPD3
Sphingomyelin phosphodiesterase 3

Protein Summary
Description
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219334
  • ENSP00000219334
  • ENSG00000103056
  • ENST00000563226
  • ENSP00000455955

Symbol
  • NSMASE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.71
PubMedID
0.67
transcription factor binding site profile
0.65
virus perturbation
0.64
phenotype
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.31   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.31   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (75)
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.999964587
p_ni:  0.000032627
p_wrong:  0.000002786
Score:  0.272
Data Source:  BioPlex,STRINGDB
ENDOD1
Tdark
Family:  Enzyme
Novelty:  0.26430864
p_int:  0.999632614
p_ni:  0.000367386
Data Source:  BioPlex
STOM
Tbio
Novelty:  0.00459891
p_int:  0.995103733
p_ni:  0.004896266
p_wrong:  1e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
TMEM135
Tdark
Novelty:  0.12811625
p_int:  0.990423176
p_ni:  2.3e-8
p_wrong:  0.009576801
Score:  0.622
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.979683809
p_ni:  0.020314888
p_wrong:  0.000001303
Score:  0.494
Data Source:  BioPlex,STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.945914046
p_ni:  0.054085954
Data Source:  BioPlex
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
p_int:  0.881405512
p_ni:  0.118594473
p_wrong:  1.5e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  0.848082204
p_ni:  0.151917796
Score:  0.656
Data Source:  BioPlex,STRINGDB
APOB
Tchem
Novelty:  0.00008247
p_int:  0.845000096
p_ni:  0.154999899
p_wrong:  4e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
RACK1
Tbio
Novelty:  0.00200617
Score:  0.966
Data Source:  Reactome,STRINGDB
Pathways (14)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.8
high density lipoprotein cholesterol measurement
1
3
3
89.9
apolipoprotein A 1 measurement
1
3
3
88.7
glomerular filtration rate
4
3
3
6.4
77.8
metabolite measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.8
high density lipoprotein cholesterol measurement
3
89.9
apolipoprotein A 1 measurement
3
88.7
glomerular filtration rate
3
6.4
77.8
metabolite measurement
1
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase 3
VGNC:9105
468008
Macaque
sphingomyelin phosphodiesterase 3
703384
Mouse
MGI:1927578
58994
Rat
RGD:619754
94338
Dog
sphingomyelin phosphodiesterase 3
VGNC:46571
489743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase 3
Macaque
sphingomyelin phosphodiesterase 3
Mouse
Rat
Dog
sphingomyelin phosphodiesterase 3
Publication Statistics
PubMed Score 131.31
PubMed score by year
PubTator Score 63.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title