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Tchem
SMPD2
Sphingomyelin phosphodiesterase 2

Protein Summary
Description
Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258052
  • ENSP00000258052
  • ENSG00000135587

Symbol
  • ISC1
  • NSMASE
  • NSMASE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
gene perturbation
0.7
small molecule perturbation
0.63
cell type or tissue
0.62
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.61   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.61   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (124)
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.998874678
p_ni:  0.001125315
p_wrong:  7e-9
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.998824579
p_ni:  0.001175281
p_wrong:  1.39e-7
Data Source:  BioPlex
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.99868335
p_ni:  0.001316601
p_wrong:  4.8e-8
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.998168158
p_ni:  0.001831697
p_wrong:  1.45e-7
Data Source:  BioPlex
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.998034548
p_ni:  0.001965273
p_wrong:  1.8e-7
Data Source:  BioPlex
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.997607254
p_ni:  0.002392202
p_wrong:  5.44e-7
Data Source:  BioPlex
TMED6
Tdark
Novelty:  0.598611
p_int:  0.997399201
p_ni:  0.002600772
p_wrong:  2.7e-8
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.997219951
p_ni:  0.002779859
p_wrong:  1.9e-7
Data Source:  BioPlex
PCDHA3
Tdark
Novelty:  0.8622898
p_int:  0.996710602
p_ni:  0.003288759
p_wrong:  6.38e-7
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.995781917
p_ni:  0.004217748
p_wrong:  3.35e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
Pathways (34)
Ceramide signalling (R-HSA-193681)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ceramide signalling
Reactome
Death Receptor Signalling
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Ceramide signalling
Death Receptor Signalling
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
80.6
mosaic loss of chromosome Y measurement
2
1
2
79.9
reticulocyte count
1
1
1
69.5
lymphocyte percentage of leukocytes
1
1
1
56.6
lymphocyte count
2
2
2
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
80.6
mosaic loss of chromosome Y measurement
2
79.9
reticulocyte count
1
69.5
lymphocyte percentage of leukocytes
1
56.6
lymphocyte count
2
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase 2
VGNC:7929
462928
Mouse
MGI:1278330
20598
Rat
RGD:619753
83537
Dog
sphingomyelin phosphodiesterase 2
VGNC:46570
100856377
Horse
sphingomyelin phosphodiesterase 2
VGNC:23354
100066652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase 2
Mouse
Rat
Dog
sphingomyelin phosphodiesterase 2
Horse
sphingomyelin phosphodiesterase 2
Publication Statistics
PubMed Score 276.61
PubMed score by year
PubTator Score 104.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title