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Tchem
SMPD1
Sphingomyelin phosphodiesterase

Protein Summary
Description
Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 lacks residues that bind the cofactor Zn(2+) and has no enzyme activity. Isoform 3 lacks residues that bind the cofactor Zn(2+) and has no enzyme activity. The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342245
  • ENSP00000340409
  • ENSG00000166311
  • ENST00000527275
  • ENSP00000435350

Symbol
  • ASM
  • ASM
  • NPD
  • ASMASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.92
biological process
0.91
disease perturbation
0.87
histone modification site profile
0.82
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.63   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.63   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (14)
Protein-Protein Interactions (125)
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.948241025
p_ni:  0.001164289
p_wrong:  0.050594686
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.865829774
p_ni:  0.134170226
Score:  0.234
Data Source:  BioPlex,STRINGDB
CNTNAP3B
Tdark
Novelty:  0.25889644
p_int:  0.836550496
p_ni:  0.16120928
p_wrong:  0.002240223
Score:  0.259
Data Source:  BioPlex,STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
p_int:  0.779177263
p_ni:  0.220822737
Score:  0.226
Data Source:  BioPlex,STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
Score:  0.979
Data Source:  STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
Score:  0.971
Data Source:  STRINGDB
SGMS2
Tchem
Family:  Enzyme
Novelty:  0.01360669
Score:  0.97
Data Source:  STRINGDB
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.966
Data Source:  STRINGDB
SGMS1
Tchem
Family:  Enzyme
Novelty:  0.01717229
Score:  0.96
Data Source:  STRINGDB
GALC
Tbio
Family:  Enzyme
Novelty:  0.00203532
Score:  0.955
Data Source:  STRINGDB
Pathways (51)
Glycosphingolipid metabolism (R-HSA-1660662)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase 1
VGNC:6549
450990
Macaque
sphingomyelin phosphodiesterase 1
711248
Mouse
MGI:98325
20597
Rat
RGD:1549719
308909
Dog
sphingomyelin phosphodiesterase 1
VGNC:46569
485334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingomyelin phosphodiesterase 1
Macaque
sphingomyelin phosphodiesterase 1
Mouse
Rat
Dog
sphingomyelin phosphodiesterase 1
Publication Statistics
PubMed Score 560.63
PubMed score by year
PubTator Score 437.03
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title