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Tbio
SMOX
Spermine oxidase

Protein Summary
Description
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative ro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278795
  • ENSP00000278795
  • ENSG00000088826
  • ENST00000305958
  • ENSP00000307252
  • ENST00000339123
  • ENSP00000344595
  • ENST00000346595
  • ENSP00000341775
  • ENST00000379460
  • ENSP00000368773
  • ENST00000621355
  • ENSP00000478305

Symbol
  • C20orf16
  • SMO
  • PAO
  • SMO
  • PAO1
  • PAOH
  • PAO-1
  • PAOH1
  • C20orf16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.79
gene perturbation
0.72
transcription factor
0.72
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.47   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.47   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
p_int:  0.998775534
p_ni:  0.000348222
p_wrong:  0.000876244
Score:  0.916
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.990112892
p_ni:  0.009887108
Score:  0.177
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.965585258
p_ni:  0.034414741
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.899222802
p_ni:  0.100777198
Score:  0.222
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.877376232
p_ni:  0.122623768
Score:  0.186
Data Source:  BioPlex,STRINGDB
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.790853188
p_ni:  0.209146812
Data Source:  BioPlex
SRM
Tchem
Family:  Enzyme
Novelty:  0.01583759
Score:  0.973
Data Source:  STRINGDB
SAT1
Tbio
Family:  Enzyme
Novelty:  0.0022456
Score:  0.973
Data Source:  STRINGDB
SMS
Tchem
Family:  Enzyme
Novelty:  0.02447112
Score:  0.964
Data Source:  STRINGDB
AOC2
Tchem
Family:  Enzyme
Novelty:  0.0048282
Score:  0.943
Data Source:  STRINGDB
Pathways (13)
Amine Oxidase reactions (R-HSA-140179)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine Oxidase reactions
Reactome
Biological oxidations
Reactome
Interconversion of polyamines
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Amine Oxidase reactions
Biological oxidations
Interconversion of polyamines
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
15
18
99.9
reticulocyte measurement
3
11
14
99.9
mean corpuscular hemoglobin concentration
1
1
1
80.7
body height
3
3
3
79.8
mean reticulocyte volume
1
1
1
76.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
18
99.9
reticulocyte measurement
14
99.9
mean corpuscular hemoglobin concentration
1
80.7
body height
3
79.8
mean reticulocyte volume
1
76.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spermine oxidase
VGNC:6314
458074
Mouse
MGI:2445356
228608
Rat
RGD:1306049
308652
Dog
spermine oxidase
VGNC:46568
485787
Horse
spermine oxidase
VGNC:23352
100052311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spermine oxidase
Mouse
Rat
Dog
spermine oxidase
Horse
spermine oxidase
Publication Statistics
PubMed Score 169.47
PubMed score by year
PubTator Score 133.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title