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Tbio
SMOC1
SPARC-related modular calcium-binding protein 1

Protein Summary
Description
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361956
  • ENSP00000355110
  • ENSG00000198732
  • ENST00000381280
  • ENSP00000370680

Symbol
  • OAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
trait
0.75
protein domain
0.73
transcription factor
0.65
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.76   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.76   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999553178
p_ni:  0.000446821
p_wrong:  1e-9
Data Source:  BioPlex
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.999204369
p_ni:  0.000795629
p_wrong:  2e-9
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.999065582
p_ni:  0.000934418
Score:  0.216
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.998727128
p_ni:  0.001272515
p_wrong:  3.57e-7
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.998454363
p_ni:  0.001545637
p_wrong:  1e-9
Data Source:  BioPlex
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.995938779
p_ni:  0.003983455
p_wrong:  0.000077767
Score:  0.175
Data Source:  BioPlex,STRINGDB
PRSS21
Tbio
Family:  Enzyme
Novelty:  0.0110251
p_int:  0.994388337
p_ni:  0.005528486
p_wrong:  0.000083178
Data Source:  BioPlex
RETNLB
Tbio
Novelty:  0.00777842
p_int:  0.988126839
p_ni:  0.011652154
p_wrong:  0.000221007
Data Source:  BioPlex
TCTN1
Tbio
Novelty:  0.0657704
p_int:  0.979389
p_ni:  0.019378685
p_wrong:  0.001232315
Data Source:  BioPlex
NAF1
Tbio
Novelty:  2.99493689
p_int:  0.973761616
p_ni:  0.026120812
p_wrong:  0.000117573
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
89.2
mean corpuscular hemoglobin concentration
1
1
1
80.6
digit length ratio
3
1
4
75.4
appendicular lean mass
1
2
2
71.4
bone density
1
1
0
2.2
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
89.2
mean corpuscular hemoglobin concentration
1
80.6
digit length ratio
4
75.4
appendicular lean mass
2
71.4
bone density
0
2.2
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPARC related modular calcium binding 1
VGNC:3315
453002
Macaque
SPARC related modular calcium binding 1
712994
Mouse
MGI:1929878
64075
Rat
RGD:1303126
314280
Dog
SPARC related modular calcium binding 1
VGNC:46566
480373
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPARC related modular calcium binding 1
Macaque
SPARC related modular calcium binding 1
Mouse
Rat
Dog
SPARC related modular calcium binding 1
Publication Statistics
PubMed Score 35.76
PubMed score by year
PubTator Score 102.53
PubTator score by year
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Related Publications
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PMID
Year
Title