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Tclin
SMO
Smoothened homolog

Protein Summary
Description
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249373
  • ENSP00000249373
  • ENSG00000128602

Symbol
  • SMOH
  • Gx
  • CRJS
  • SMOH
  • FZD11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
histone modification site profile
0.84
PubMedID
0.82
phosphatase
0.81
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 64
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 349
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4