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Tdark
SMIM14
Small integral membrane protein 14

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295958
  • ENSP00000295958
  • ENSG00000163683

Symbol
  • C4orf34
  • C4orf34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.82
cell type or tissue
0.77
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
CNPPD1
Tdark
Novelty:  1.33885532
Score:  0.625
Data Source:  STRINGDB
TMEM131L
Tbio
Novelty:  0.60395527
Score:  0.616
Data Source:  STRINGDB
TIGD4
Tdark
Novelty:  1.81608844
Score:  0.603
Data Source:  STRINGDB
OCIAD2
Tbio
Novelty:  0.19380887
Score:  0.552
Data Source:  STRINGDB
WDR78
Tdark
Novelty:  0.15324005
Score:  0.551
Data Source:  STRINGDB
TMEM156
Tdark
Novelty:  1.38254197
Score:  0.548
Data Source:  STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
Score:  0.518
Data Source:  STRINGDB
ARFIP1
Tbio
Novelty:  0.20178246
Score:  0.512
Data Source:  STRINGDB
FAM114A1
Tbio
Novelty:  0.37607254
Score:  0.511
Data Source:  STRINGDB
FBLL1
Tdark
Family:  Enzyme
Novelty:  1.53294318
Score:  0.51
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
54
high density lipoprotein cholesterol measurement
2
2
2
51.2
1
1
0
4.9
45.3
response to tofacitinib
1
1
0
4.9
45.3
corneal resistance factor
1
1
1
40.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
54
high density lipoprotein cholesterol measurement
2
51.2
0
4.9
45.3
response to tofacitinib
0
4.9
45.3
corneal resistance factor
1
40.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small integral membrane protein 14
746169
Macaque
small integral membrane protein 14
106998314
Mouse
MGI:1915802
68552
Rat
RGD:1311122
364154
Dog
small integral membrane protein 14
VGNC:46559
479105
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small integral membrane protein 14
Macaque
small integral membrane protein 14
Mouse
Rat
Dog
small integral membrane protein 14
Publication Statistics
PubMed Score 1.25
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title