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Tbio
SMG7
Protein SMG7

Protein Summary
Description
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347615
  • ENSP00000340766
  • ENSG00000116698
  • ENST00000507469
  • ENSP00000425133
  • ENST00000508461
  • ENSP00000426915
  • ENST00000515829
  • ENSP00000421358

Symbol
  • C1orf16
  • EST1C
  • KIAA0250
  • EST1C
  • SGA56M
  • C1orf16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
histone modification site profile
0.81
transcription factor
0.8
co-expressed gene
0.76
microRNA
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.83   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.83   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999900914
p_ni:  0.000099035
p_wrong:  5.1e-8
Data Source:  BioPlex
KLK15
Tbio
Family:  Enzyme
Novelty:  0.00083978
p_int:  0.999489597
p_ni:  0.000510393
p_wrong:  1e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
p_int:  0.999002021
p_ni:  0.000997952
p_wrong:  2.8e-8
Data Source:  BioPlex
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
p_int:  0.998966973
p_ni:  0.001032952
p_wrong:  7.5e-8
Score:  0.422
Data Source:  BioPlex,STRINGDB
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.998393677
p_ni:  0.001606306
p_wrong:  1.8e-8
Data Source:  BioPlex
TSNAX
Tbio
Novelty:  0.00888891
p_int:  0.995228655
p_ni:  0.004195097
p_wrong:  0.000576248
Score:  0.223
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.991595816
p_ni:  0.007036351
p_wrong:  0.001367834
Score:  0.343
Data Source:  BioPlex,STRINGDB
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.966081907
p_ni:  0.033910348
p_wrong:  0.000007745
Data Source:  BioPlex
SMG1
Tchem
Family:  Kinase
Novelty:  0.00854339
Score:  0.999
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
2
97.2
1
1
0
1.4
66.8
1
1
0
1.4
63.7
1
1
0
1.4
63.7
1
1
0
1.4
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
97.2
0
1.4
66.8
0
1.4
63.7
0
1.4
63.7
0
1.4
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMG7, nonsense mediated mRNA decay factor
VGNC:1556
457572
Macaque
SMG7, nonsense mediated mRNA decay factor
717603
Mouse
MGI:2682334
226517
Rat
RGD:1310761
360855
Dog
SMG7, nonsense mediated mRNA decay factor
VGNC:46557
480035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMG7, nonsense mediated mRNA decay factor
Macaque
SMG7, nonsense mediated mRNA decay factor
Mouse
Rat
Dog
SMG7, nonsense mediated mRNA decay factor
Publication Statistics
PubMed Score 31.83
PubMed score by year
PubTator Score 11.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title