Protein Summary
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [p ...more
- ENST00000347615
- ENSP00000340766
- ENSG00000116698
- ENST00000507469
- ENSP00000425133
- ENST00000508461
- ENSP00000426915
- ENST00000515829
- ENSP00000421358
- C1orf16
- EST1C
- KIAA0250
- EST1C
- SGA56M
- C1orf16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.98 | ||
histone modification site profile | 0.81 | ||
transcription factor | 0.8 | ||
co-expressed gene | 0.76 | ||
microRNA | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.83 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 89 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.83 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 89 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (192)
CRYAA
Novelty: 0.01914081
p_int: 0.999900914
p_ni: 0.000099035
p_wrong: 5.1e-8
Data Source: BioPlex
KLK15
Family: Enzyme
Novelty: 0.00083978
p_int: 0.999489597
p_ni: 0.000510393
p_wrong: 1e-8
Score: 0.332
Data Source: BioPlex,STRINGDB
NPAS1
Family: TF
Novelty: 0.08014425
p_int: 0.999002021
p_ni: 0.000997952
p_wrong: 2.8e-8
Data Source: BioPlex
DNA2
Family: Enzyme
Novelty: 0.00195682
p_int: 0.998966973
p_ni: 0.001032952
p_wrong: 7.5e-8
Score: 0.422
Data Source: BioPlex,STRINGDB
C6orf141
Novelty: 1.46022784
p_int: 0.998393677
p_ni: 0.001606306
p_wrong: 1.8e-8
Data Source: BioPlex
TSNAX
Novelty: 0.00888891
p_int: 0.995228655
p_ni: 0.004195097
p_wrong: 0.000576248
Score: 0.223
Data Source: BioPlex,STRINGDB
CDC16
Novelty: 0.00916715
p_int: 0.991595816
p_ni: 0.007036351
p_wrong: 0.001367834
Score: 0.343
Data Source: BioPlex,STRINGDB
CRYL1
Family: Enzyme
Novelty: 0.04513297
p_int: 0.966081907
p_ni: 0.033910348
p_wrong: 0.000007745
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | ||||
Reactome | Nonsense-Mediated Decay (NMD) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism of RNA | ||||
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | ||||
Nonsense-Mediated Decay (NMD) | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (5)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
6 | 3 | 0 | 2 | 97.2 | |||||
1 | 1 | 0 | 1.4 | 66.8 | |||||
1 | 1 | 0 | 1.4 | 63.7 | |||||
1 | 1 | 0 | 1.4 | 63.7 | |||||
1 | 1 | 0 | 1.4 | 63.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 2 | 97.2 | |||||
0 | 1.4 | 66.8 | |||||
0 | 1.4 | 63.7 | |||||
0 | 1.4 | 63.7 | |||||
0 | 1.4 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SMG7, nonsense mediated mRNA decay factor | VGNC:1556 | 457572 | |||||
Macaque | SMG7, nonsense mediated mRNA decay factor | 717603 | ||||||
Mouse | MGI:2682334 | 226517 | ||||||
Rat | RGD:1310761 | 360855 | ||||||
Dog | SMG7, nonsense mediated mRNA decay factor | VGNC:46557 | 480035 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SMG7, nonsense mediated mRNA decay factor | |||||
Macaque | SMG7, nonsense mediated mRNA decay factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | SMG7, nonsense mediated mRNA decay factor | |||||
Publication Statistics
PubMed Score 31.83
PubMed score by year
PubTator Score 11.19
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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