Tbio SMG7 Protein SMG7

Protein Summary

Description

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q92540
• B4DRB2
• E9PCI0
• E9PEH2
• Q5T1Q0
• Q6PIE0
• Q7Z7H9
• Q8IXC1
• Q8IXC2

Gene Name

• SMG7

Ensembl ID

• ENST00000347615
• ENSP00000340766
• ENSG00000116698
• ENST00000507469
• ENSP00000425133
• ENST00000508461
• ENSP00000426915
• ENST00000515829
• ENSP00000421358

Symbol

• C1orf16
• EST1C
• KIAA0250
• EST1C
• SGA56M
• C1orf16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
histone modification site profile	0.81
transcription factor	0.8
co-expressed gene	0.76
microRNA	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.16   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.16   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0