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Tbio
SMG5
Protein SMG5

Protein Summary
Description
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361813
  • ENSP00000355261
  • ENSG00000198952

Symbol
  • EST1B
  • KIAA1089
  • EST1B
  • SMG-5
  • LPTSRP1
  • LPTS-RP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
disease perturbation
0.87
transcription factor binding site profile
0.85
histone modification site profile
0.76
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.9999999
p_ni:  1.9e-8
p_wrong:  8.2e-8
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.948067824
p_ni:  0.000008186
p_wrong:  0.05192399
Score:  0.188
Data Source:  BioPlex,STRINGDB
UPF3A
Tbio
Novelty:  0.01431609
Score:  0.999
Data Source:  STRINGDB
UPF3B
Tbio
Novelty:  0.03482348
Score:  0.999
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.998
Data Source:  STRINGDB
UPF2
Tbio
Novelty:  0.01064562
Score:  0.994
Data Source:  STRINGDB
SMG1
Tchem
Family:  Kinase
Novelty:  0.00854339
Score:  0.993
Data Source:  STRINGDB
SMG9
Tbio
Novelty:  0.03940774
Score:  0.989
Data Source:  STRINGDB
SMG8
Tdark
Novelty:  0.18080965
Score:  0.989
Data Source:  STRINGDB
TERT
Tchem
Family:  Enzyme
Novelty:  0.00024411
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
94.7
HbA1c measurement
5
5
5
92
mean corpuscular volume
2
2
2
90.1
mean corpuscular hemoglobin concentration
3
3
3
81.7
serum urea measurement
1
2
2
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
94.7
HbA1c measurement
5
92
mean corpuscular volume
2
90.1
mean corpuscular hemoglobin concentration
3
81.7
serum urea measurement
2
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMG5, nonsense mediated mRNA decay factor
VGNC:1555
107968716
Macaque
SMG5, nonsense mediated mRNA decay factor
719446
Mouse
MGI:2447364
229512
Rat
RGD:1584731
681012
Dog
SMG5, nonsense mediated mRNA decay factor
VGNC:46555
490414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMG5, nonsense mediated mRNA decay factor
Macaque
SMG5, nonsense mediated mRNA decay factor
Mouse
Rat
Dog
SMG5, nonsense mediated mRNA decay factor
Publication Statistics
PubMed Score 19.39
PubMed score by year
PubTator Score 8.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title