Protein Summary
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]
- ENST00000361813
- ENSP00000355261
- ENSG00000198952
- EST1B
- KIAA1089
- EST1B
- SMG-5
- LPTSRP1
- LPTS-RP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.85 | ||
histone modification site profile | 0.76 | ||
tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.39 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 105 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.39 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 105 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (176)
C6orf141
Novelty: 1.46022784
p_int: 0.948067824
p_ni: 0.000008186
p_wrong: 0.05192399
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (3)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | ||||
Reactome | Nonsense-Mediated Decay (NMD) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of RNA | ||||
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | ||||
Nonsense-Mediated Decay (NMD) | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (7)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 94.7 | |||||
HbA1c measurement | 5 | 5 | 5 | 92 | |||||
mean corpuscular volume | 2 | 2 | 2 | 90.1 | |||||
mean corpuscular hemoglobin concentration | 3 | 3 | 3 | 81.7 | |||||
serum urea measurement | 1 | 2 | 2 | 75.4 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 94.7 | |||||
HbA1c measurement | 5 | 92 | |||||
mean corpuscular volume | 2 | 90.1 | |||||
mean corpuscular hemoglobin concentration | 3 | 81.7 | |||||
serum urea measurement | 2 | 75.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SMG5, nonsense mediated mRNA decay factor | VGNC:1555 | 107968716 | |||||
Macaque | SMG5, nonsense mediated mRNA decay factor | 719446 | ||||||
Mouse | MGI:2447364 | 229512 | ||||||
Rat | RGD:1584731 | 681012 | ||||||
Dog | SMG5, nonsense mediated mRNA decay factor | VGNC:46555 | 490414 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SMG5, nonsense mediated mRNA decay factor | |||||
Macaque | SMG5, nonsense mediated mRNA decay factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | SMG5, nonsense mediated mRNA decay factor | |||||
Publication Statistics
PubMed Score 19.39
PubMed score by year
PubTator Score 8.02
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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