You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SMC6
Structural maintenance of chromosomes protein 6

Protein Summary
Description
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351948
  • ENSP00000323439
  • ENSG00000163029
  • ENST00000402989
  • ENSP00000384539
  • ENST00000448223
  • ENSP00000404092

Symbol
  • SMC6L1
  • SMC-6
  • hSMC6
  • SMC6L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.95
virus perturbation
0.94
histone modification site profile
0.89
molecular function
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.63   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.63   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (193)
NSMCE1
Tdark
Novelty:  0.75370409
p_int:  0.999999956
p_ni:  4.3e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF597
Tbio
Family:  TF
Novelty:  0.04420398
p_int:  0.999999802
p_ni:  1.98e-7
Score:  0.843
Data Source:  BioPlex,STRINGDB
EID3
Tdark
Novelty:  0.37412011
p_int:  0.999989449
p_ni:  0.000010551
Score:  0.996
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999279554
p_ni:  0.000720446
Score:  0.618
Data Source:  BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  0.997547505
p_ni:  0.002452494
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.993068524
p_ni:  0.006931476
Score:  0.729
Data Source:  BioPlex,STRINGDB
PJA1
Tbio
Family:  Enzyme
Novelty:  0.06148437
p_int:  0.990594071
p_ni:  0.009405929
Score:  0.639
Data Source:  BioPlex,STRINGDB
MUM1
Tbio
Family:  Epigenetic
Novelty:  0.11597088
p_int:  0.944319593
p_ni:  0.050646032
p_wrong:  0.005034374
Score:  0.325
Data Source:  BioPlex,STRINGDB
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.849816264
p_ni:  0.111546236
p_wrong:  0.0386375
Score:  0.16
Data Source:  BioPlex,STRINGDB
ERH
Tbio
Novelty:  0.00711649
p_int:  0.77385923
p_ni:  0.108453189
p_wrong:  0.117687581
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of DNA damage response and repair proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
54.4
mathematical ability
2
1
2
31.4
total cholesterol measurement
1
1
1
24.5
energy expenditure measurement
1
1
0
124
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
54.4
mathematical ability
2
31.4
total cholesterol measurement
1
24.5
energy expenditure measurement
0
124
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 6
VGNC:378
459046
Macaque
structural maintenance of chromosomes 6
699570
Mouse
MGI:1914491
67241
Rat
RGD:1311214
313961
Dog
structural maintenance of chromosomes 6
VGNC:46547
475675
Species
Name
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 6
Macaque
structural maintenance of chromosomes 6
Mouse
Rat
Dog
structural maintenance of chromosomes 6
Publication Statistics
PubMed Score 38.63
PubMed score by year
PubTator Score 39.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title