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Tchem
SMC2
Structural maintenance of chromosomes protein 2

Protein Summary
Description
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286398
  • ENSP00000286398
  • ENSG00000136824
  • ENST00000374787
  • ENSP00000363919
  • ENST00000374793
  • ENSP00000363925

Symbol
  • CAPE
  • SMC2L1
  • CAPE
  • CAP-E
  • SMC-2
  • SMC2L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
protein complex
0.88
co-expressed gene
0.82
molecular function
0.81
cellular component
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1