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Tbio
SMARCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264640
  • ENSP00000466608
  • ENSG00000073584
  • ENST00000348513
  • ENSP00000323967
  • ENST00000377808
  • ENSP00000367039
  • ENST00000400122
  • ENSP00000411607
  • ENST00000447024
  • ENSP00000392958
  • ENST00000578044
  • ENSP00000464511
  • ENST00000643318
  • ENSP00000494771
  • ENST00000643683
  • ENSP00000496094
  • ENST00000644701
  • ENSP00000496097
  • ENST00000647508
  • ENSP00000496445

Symbol
  • BAF57
  • CSS5
  • BAF57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
molecular function
0.99
transcription factor perturbation
0.97
kinase perturbation
0.91
histone modification site profile
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.95   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.95   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
BRD7
Tchem
Family:  Epigenetic
Novelty:  0.01820848
p_int:  0.999997064
p_ni:  0.000002936
Score:  0.995
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999996828
p_ni:  0.000003172
Score:  0.985
Data Source:  BioPlex,STRINGDB
DPF2
Tbio
Family:  Epigenetic
Novelty:  0.0403366
p_int:  0.999995508
p_ni:  0.000004492
Score:  0.955
Data Source:  BioPlex,STRINGDB
ARID2
Tbio
Family:  TF
Novelty:  0.01767212
p_int:  0.999961312
p_ni:  0.000038687
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
PBRM1
Tchem
Family:  TF; Epigenetic
Novelty:  0.00608093
p_int:  0.999926179
p_ni:  0.000073821
Score:  0.995
Data Source:  BioPlex,STRINGDB
ARID1B
Tbio
Family:  TF
Novelty:  0.00731933
p_int:  0.999915511
p_ni:  0.000084489
Score:  0.997
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999909524
p_ni:  0.000090476
Score:  0.994
Data Source:  BioPlex,STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
p_int:  0.99981615
p_ni:  0.00018385
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
0
1.1
96
5
4
2
1.1
91.5
3
2
0
1.3
83.5
Eczema
3
2
0
1.3
83.5
lymphocyte percentage of leukocytes
2
2
3
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
96
2
1.1
91.5
0
1.3
83.5
Eczema
0
1.3
83.5
lymphocyte percentage of leukocytes
3
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
VGNC:9635
454655
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
701310
Mouse
MGI:1927347
57376
Rat
RGD:1304726
303518
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
VGNC:46540
608250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Publication Statistics
PubMed Score 62.95
PubMed score by year
PubTator Score 37.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title