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Tbio
SMARCC2
SWI/SNF complex subunit SMARCC2

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267064
  • ENSP00000267064
  • ENSG00000139613
  • ENST00000347471
  • ENSP00000302919
  • ENST00000394023
  • ENSP00000377591

Symbol
  • BAF170
  • CSS8
  • Rsc8
  • BAF170
  • CRACC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein complex
1
protein domain
0.97
molecular function
0.94
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.33   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.33   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  1
Score:  0.984
Data Source:  BioPlex,STRINGDB
DPF2
Tbio
Family:  Epigenetic
Novelty:  0.0403366
p_int:  0.999999995
p_ni:  5e-9
Score:  0.944
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
BRD7
Tchem
Family:  Epigenetic
Novelty:  0.01820848
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999999892
p_ni:  1.08e-7
Score:  0.89
Data Source:  BioPlex,STRINGDB
DPF1
Tbio
Family:  Epigenetic
Novelty:  0.0713809
p_int:  0.99999966
p_ni:  3.29e-7
p_wrong:  1.1e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
ARID2
Tbio
Family:  TF
Novelty:  0.01767212
p_int:  0.999999144
p_ni:  8.55e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999999079
p_ni:  9.21e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
PBRM1
Tchem
Family:  TF; Epigenetic
Novelty:  0.00608093
p_int:  0.999998385
p_ni:  0.000001615
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
6
6
97.7
3
2
0
1.3
89.2
body mass index
3
2
3
75
2
2
0
1.2
73.9
smoking status measurement
2
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
97.7
0
1.3
89.2
body mass index
3
75
0
1.2
73.9
smoking status measurement
2
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
VGNC:10372
451985
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
709158
Mouse
MGI:1915344
68094
Rat
RGD:1597704
685179
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
VGNC:46536
481107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
Publication Statistics
PubMed Score 33.33
PubMed score by year
PubTator Score 12.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title