You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SMARCB1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Protein Summary
Description
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407422
  • ENSP00000383984
  • ENSG00000099956
  • ENST00000618915
  • ENSP00000479330
  • ENSG00000275837
  • ENST00000631333
  • ENSP00000486870
  • ENST00000644036
  • ENSP00000494049

Symbol
  • BAF47
  • INI1
  • SNF5L1
  • RDT
  • CSS3
  • INI1
  • SNF5
  • Snr1
  • BAF47
  • MRD15
  • RTPS1
  • Sfh1p
  • hSNFS
  • SNF5L1
  • SWNTS1
  • PPP1R144
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
virus
0.98
disease perturbation
0.97
protein complex
0.97
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1173.87   (req: < 5)
Gene RIFs: 212   (req: <= 3)
Antibodies: 471   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1173.87   (req: >= 5)
Gene RIFs: 212   (req: > 3)
Antibodies: 471   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0