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Tbio
SMARCB1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Protein Summary
Description
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407422
  • ENSP00000383984
  • ENSG00000099956
  • ENST00000618915
  • ENSP00000479330
  • ENSG00000275837
  • ENST00000631333
  • ENSP00000486870
  • ENST00000644036
  • ENSP00000494049

Symbol
  • BAF47
  • INI1
  • SNF5L1
  • RDT
  • CSS3
  • INI1
  • SNF5
  • Snr1
  • BAF47
  • MRD15
  • RTPS1
  • Sfh1p
  • hSNFS
  • SNF5L1
  • SWNTS1
  • PPP1R144
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
virus
0.98
disease perturbation
0.97
protein complex
0.97
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.26   (req: < 5)
Gene RIFs: 212   (req: <= 3)
Antibodies: 471   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.26   (req: >= 5)
Gene RIFs: 212   (req: > 3)
Antibodies: 471   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (282)
BRD7
Tchem
Family:  Epigenetic
Novelty:  0.01820848
p_int:  0.999999993
p_ni:  8e-9
Score:  0.889
Data Source:  BioPlex,STRINGDB
ARID1B
Tbio
Family:  TF
Novelty:  0.00731933
p_int:  0.999999103
p_ni:  8.97e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
DPF1
Tbio
Family:  Epigenetic
Novelty:  0.0713809
p_int:  0.999999003
p_ni:  9.95e-7
p_wrong:  2e-9
Score:  0.972
Data Source:  BioPlex,STRINGDB
PBRM1
Tchem
Family:  TF; Epigenetic
Novelty:  0.00608093
p_int:  0.999998322
p_ni:  0.000001678
Score:  0.995
Data Source:  BioPlex,STRINGDB
ARID2
Tbio
Family:  TF
Novelty:  0.01767212
p_int:  0.999996356
p_ni:  0.000003644
Score:  0.993
Data Source:  BioPlex,STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
p_int:  0.999993561
p_ni:  0.000006439
Score:  0.998
Data Source:  BioPlex,STRINGDB
KIF22
Tbio
Novelty:  0.0109594
p_int:  0.999993043
p_ni:  0.000006955
p_wrong:  2e-9
Data Source:  BioPlex
BCL7B
Tbio
Novelty:  0.11909054
p_int:  0.99999224
p_ni:  0.00000776
Score:  0.928
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999991236
p_ni:  0.000008198
p_wrong:  5.67e-7
Score:  0.974
Data Source:  BioPlex,STRINGDB
SMARCD2
Tbio
Novelty:  0.04006597
p_int:  0.999991027
p_ni:  0.000008973
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
5
5
96.3
serum gamma-glutamyl transferase measurement
2
5
5
96.3
serum IgG glycosylation measurement
1
1
1
82.8
serum IgG glycosylation measurement
1
1
1
82.8
serum non-albumin protein measurement
1
2
2
76.7
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
96.3
serum gamma-glutamyl transferase measurement
5
96.3
serum IgG glycosylation measurement
1
82.8
serum IgG glycosylation measurement
1
82.8
serum non-albumin protein measurement
2
76.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
VGNC:12923
458702
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
699190
Mouse
MGI:1328366
20587
Rat
RGD:1308761
361825
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
VGNC:46534
486407
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Publication Statistics
PubMed Score 1004.26
PubMed score by year
PubTator Score 633.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title