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Tbio
SMARCA1
Probable global transcription activator SNF2L1

Protein Summary
Description
Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371122
  • ENSP00000360163
  • ENSG00000102038

Symbol
  • SNF2L
  • SNF2L1
  • SWI
  • ISWI
  • SWI2
  • SNF2L
  • SNF2L1
  • SNF2LB
  • SNF2LT
  • hSNF2L
  • NURF140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
ligand (protein) perturbation
0.96
transcription factor perturbation
0.96
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.08   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.08   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999982723
p_ni:  0.000017277
Score:  0.804
Data Source:  BioPlex,STRINGDB
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
p_int:  0.999578883
p_ni:  0.000421117
Score:  0.845
Data Source:  BioPlex,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.996740732
p_ni:  0.003259268
Score:  0.171
Data Source:  BioPlex,STRINGDB
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.966237043
p_ni:  0.033762957
Score:  0.165
Data Source:  BioPlex,STRINGDB
IDO2
Tchem
Family:  Enzyme
Novelty:  0.01141558
p_int:  0.87495148
p_ni:  0.12504852
Score:  0.187
Data Source:  BioPlex,STRINGDB
INAVA
Tbio
Novelty:  0.19311978
p_int:  0.859197188
p_ni:  0.140068089
p_wrong:  0.000734723
Score:  0.183
Data Source:  BioPlex,STRINGDB
RFXANK
Tbio
Novelty:  0.00355465
p_int:  0.818940334
p_ni:  0.181059666
Score:  0.278
Data Source:  BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty:  0.02974299
p_int:  0.790922388
p_ni:  0.209077612
Score:  0.336
Data Source:  BioPlex,STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.997
Data Source:  STRINGDB
BAZ1A
Tbio
Family:  Epigenetic
Novelty:  0.01833837
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to darapladib
1
1
0
4.1
3.4
Diarrhea
1
1
0
4.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to darapladib
0
4.1
3.4
Diarrhea
0
4.1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
100430685
Mouse
MGI:1935127
93761
Rat
RGD:1561046
317575
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
VGNC:46528
481046
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
VGNC:23317
100054822
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Publication Statistics
PubMed Score 224.08
PubMed score by year
PubTator Score 72.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title