Tbio SMAP1 Stromal membrane-associated protein 1

Protein Summary

Description

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IYB5
• Q53H70
• Q5SYQ2
• Q6PK24
• Q8NDH4
• Q96L38
• Q96L39
• Q9H8X4

Gene Name

• SMAP1

Ensembl ID

• ENST00000316999
• ENSP00000313382
• ENSG00000112305
• ENST00000370452
• ENSP00000359481
• ENST00000370455
• ENSP00000359484

Symbol

• SMAP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor perturbation	0.88
disease perturbation	0.74
histone modification site profile	0.67
transcription factor binding site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0