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Tbio
SMAD9
Mothers against decapentaplegic homolog 9

Protein Summary
Description
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350148
  • ENSP00000239885
  • ENSG00000120693
  • ENST00000379826
  • ENSP00000369154
  • ENST00000399275
  • ENSP00000382216

Symbol
  • MADH6
  • MADH9
  • SMAD8
  • PPH2
  • MADH6
  • MADH9
  • SMAD8
  • SMAD8A
  • SMAD8B
  • SMAD8/9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.8
virus perturbation
0.79
tissue sample
0.68
cellular component
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 766.77   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 766.77   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0