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Tbio
SMAD7
Mothers against decapentaplegic homolog 7

Protein Summary
Description
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262158
  • ENSP00000262158
  • ENSG00000101665
  • ENST00000589634
  • ENSP00000467621
  • ENST00000591805
  • ENSP00000466902

Symbol
  • MADH7
  • MADH8
  • CRCS3
  • MADH7
  • MADH8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
hub protein
0.95
PubMedID
0.95
gene perturbation
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1019.17   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1019.17   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0