Tbio SMAD1 Mothers against decapentaplegic homolog 1

Protein Summary

Description

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15797
• A8KAJ0
• D3DNZ9
• Q16636
• Q9UFT8
• MAD homolog 1

Gene Name

• SMAD1

Ensembl ID

• ENST00000302085
• ENSP00000305769
• ENSG00000170365
• ENST00000394092
• ENSP00000377652
• ENST00000515385
• ENSP00000426568

Symbol

• BSP1
• MADH1
• MADR1
• BSP1
• JV41
• BSP-1
• JV4-1
• MADH1
• MADR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	0.99
biological process	0.98
phosphatase	0.98
virus perturbation	0.97

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mothers Against Decapentaplegic Homolog 1

DTO Classes

Protein / Transcription Factor / Mothers Against Decapentaplegic Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.72   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 1217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.72   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 1217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0