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Tbio
SLURP1
Secreted Ly-6/uPAR-related protein 1

Protein Summary
Description
Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896). The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246515
  • ENSP00000246515
  • ENSG00000126233

Symbol
  • ARS
  • ARS
  • MDM
  • ANUP
  • ArsB
  • LY6LS
  • LY6-MT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
tissue
0.53
biological term
0.48
disease
0.43
chemical
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.03   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.03   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
LYPD6
Tbio
Novelty:  0.13867181
Score:  0.901
Data Source:  STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.866
Data Source:  STRINGDB
LYNX1
Tbio
Novelty:  0.03294539
Score:  0.807
Data Source:  STRINGDB
GML
Tdark
Novelty:  0.04982168
Score:  0.751
Data Source:  STRINGDB
LYPD1
Tbio
Novelty:  0.10740408
Score:  0.742
Data Source:  STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.728
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.697
Data Source:  STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.669
Data Source:  STRINGDB
PATE4
Tdark
Novelty:  0.36651579
Score:  0.664
Data Source:  STRINGDB
CAPN3
Tbio
Novelty:  0.00318437
Score:  0.642
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.3
92.4
1
1
0
1.4
80.9
pepsinogen I/II ratio
1
1
1
78.1
2
2
2
70.4
3
2
0
1.1
60.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
92.4
0
1.4
80.9
pepsinogen I/II ratio
1
78.1
2
70.4
0
1.1
60.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
secreted LY6/PLAUR domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18746]
Mouse
MGI:1930923
57277
Rat
RGD:1308768
300016
Dog
secreted LY6/PLAUR domain containing 1
VGNC:46516
482069
Cow
secreted LY6/PLAUR domain containing 1
VGNC:34972
618706
Species
Name
OMA
EggNOG
Inparanoid
Macaque
secreted LY6/PLAUR domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18746]
Mouse
Rat
Dog
secreted LY6/PLAUR domain containing 1
Cow
secreted LY6/PLAUR domain containing 1
Publication Statistics
PubMed Score 165.03
PubMed score by year
PubTator Score 262.34
PubTator score by year
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Related Publications
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PMID
Year
Title