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Tbio
SLU7
Pre-mRNA-splicing factor SLU7

Protein Summary
Description
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297151
  • ENSP00000297151
  • ENSG00000164609

Symbol
  • 9G8
  • hSlu7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
disease perturbation
0.87
cell type or tissue
0.81
virus perturbation
0.79
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.45   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.45   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (292)
PPIL3
Tbio
Family:  Enzyme
Novelty:  0.09773948
p_int:  0.999999996
p_ni:  4e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
PRPF8
Tbio
Novelty:  0.01717158
Score:  0.999
Data Source:  STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
Score:  0.999
Data Source:  STRINGDB
CDC40
Tbio
Novelty:  0.03139044
Score:  0.999
Data Source:  STRINGDB
RBM22
Tbio
Novelty:  0.0536968
Score:  0.998
Data Source:  STRINGDB
SYF2
Tbio
Novelty:  0.06114903
Score:  0.998
Data Source:  STRINGDB
XAB2
Tbio
Novelty:  0.04104647
Score:  0.998
Data Source:  STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
Score:  0.998
Data Source:  STRINGDB
CWC22
Tbio
Novelty:  0.027689
Score:  0.998
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
0
1.3
89.4
2
2
0
1.1
80.3
Eczema
2
2
0
1.1
80.3
3
2
0
1.1
80.3
eosinophil count
2
3
3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
89.4
0
1.1
80.3
Eczema
0
1.1
80.3
0
1.1
80.3
eosinophil count
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLU7 homolog, splicing factor
VGNC:4166
737318
Macaque
SLU7 homolog, splicing factor
696023
Mouse
MGI:2385598
193116
Rat
RGD:631432
303057
Dog
SLU7 homolog, splicing factor
VGNC:46515
479308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLU7 homolog, splicing factor
Macaque
SLU7 homolog, splicing factor
Mouse
Rat
Dog
SLU7 homolog, splicing factor
Publication Statistics
PubMed Score 28.45
PubMed score by year
PubTator Score 62.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title