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Tbio
SLTM
SAFB-like transcription modulator

Protein Summary
Description
When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.98
kinase perturbation
0.97
transcription factor binding site profile
0.89
ligand (protein) perturbation
0.83
cell type or tissue
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999978745
p_ni:  0.000021255
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999294691
p_ni:  0.000705309
p_wrong:  1e-9
Data Source:  BioPlex
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999274237
p_ni:  0.000725763
Data Source:  BioPlex
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.999099401
p_ni:  0.000900599
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.996216828
p_ni:  0.00378316
p_wrong:  1.2e-8
Data Source:  BioPlex
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.967326217
p_ni:  0.032087094
p_wrong:  0.000586689
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.967214662
p_ni:  0.032785041
p_wrong:  2.97e-7
Score:  0.422
Data Source:  BioPlex,STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.966329569
p_ni:  0.011082026
p_wrong:  0.022588405
Score:  0.239
Data Source:  BioPlex,STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.964959204
p_ni:  0.034714671
p_wrong:  0.000326125
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.964551613
p_ni:  0.018006693
p_wrong:  0.017441694
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
5
7
1.1
60.2
phosphatidylethanolamine measurement
1
1
1
33.1
apolipoprotein A 1 measurement
1
1
1
30.2
cigarettes per day measurement
2
1
2
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
1.1
60.2
phosphatidylethanolamine measurement
1
33.1
apolipoprotein A 1 measurement
1
30.2
cigarettes per day measurement
2
13.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAFB like transcription modulator
VGNC:6468
453475
Macaque
SAFB like transcription modulator
701841
Mouse
MGI:1913910
66660
Dog
SAFB like transcription modulator
VGNC:46514
478322
Horse
SAFB like transcription modulator
VGNC:23307
100068259
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAFB like transcription modulator
Macaque
SAFB like transcription modulator
Mouse
Dog
SAFB like transcription modulator
Horse
SAFB like transcription modulator
Publication Statistics
PubMed Score 10.19
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
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PMID
Year
Title