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Tbio
SLMAP
Sarcolemmal membrane-associated protein

Protein Summary
Description
May play a role during myoblast fusion. This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295951
  • ENSP00000295951
  • ENSG00000163681
  • ENST00000295952
  • ENSP00000295952
  • ENST00000383718
  • ENSP00000373224
  • ENST00000428312
  • ENSP00000398661
  • ENST00000449503
  • ENSP00000412945

Symbol
  • KIAA1601
  • SLAP
  • SLAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor binding site profile
0.82
histone modification site profile
0.8
transcription factor perturbation
0.74
tissue
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
STRN
Tbio
Novelty:  0.01025814
p_int:  0.999999988
p_ni:  1.3e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
STRN3
Tbio
Novelty:  0.10331283
p_int:  0.999998986
p_ni:  0.000001014
Score:  0.958
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999998063
p_ni:  0.000001937
Score:  0.659
Data Source:  BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.999996643
p_ni:  0.000003357
Data Source:  BioPlex
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999991818
p_ni:  0.000008183
Score:  0.929
Data Source:  BioPlex,STRINGDB
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.999991223
p_ni:  0.000008777
Score:  0.883
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.999975857
p_ni:  0.000024143
Data Source:  BioPlex
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.999954543
p_ni:  0.000045457
Score:  0.829
Data Source:  BioPlex,STRINGDB
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.999908841
p_ni:  0.000091159
Score:  0.152
Data Source:  BioPlex,STRINGDB
PLP1
Tbio
Novelty:  0.00129083
p_int:  0.999888436
p_ni:  0.000111564
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
2
2
88.8
reticulocyte measurement
1
1
1
79.5
reticulocyte count
1
1
1
78.3
FEV/FEC ratio
1
1
1
71.6
vital capacity
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
88.8
reticulocyte measurement
1
79.5
reticulocyte count
1
78.3
FEV/FEC ratio
1
71.6
vital capacity
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcolemma associated protein
VGNC:2565
460474
Macaque
sarcolemma associated protein
703086
Mouse
MGI:1933549
83997
Rat
RGD:1307674
290533
Dog
sarcolemma associated protein
VGNC:46513
476577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcolemma associated protein
Macaque
sarcolemma associated protein
Mouse
Rat
Dog
sarcolemma associated protein
Publication Statistics
PubMed Score 28.05
PubMed score by year
PubTator Score 9.99
PubTator score by year
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Related Publications
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PMID
Year
Title