Tchem SLCO4C1 Solute carrier organic anion transporter family member 4C1

Protein Summary

Description

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6ZQN7
• Q86UG5

Gene Name

• SLCO4C1

Ensembl ID

• ENST00000310954
• ENSP00000309741
• ENSG00000173930

Symbol

• OATP4C1
• OATPX
• SLC21A20
• OATPX
• OATP-H
• OATP-M1
• OATP4C1
• PRO2176
• SLC21A20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.7
histone modification site profile	0.64
gene perturbation	0.63
microRNA	0.62
cell type or tissue	0.57

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 4c1

Protein / ... / Protease Inhibitor / Solute Carrier Organic Anion Transporter Family Member 4c1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 4c1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.47   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.47   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1