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Tbio
SLC9A8
Sodium/hydrogen exchanger 8

Protein Summary
Description
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361573
  • ENSP00000354966
  • ENSG00000197818
  • ENST00000417961
  • ENSP00000416418

Symbol
  • KIAA0939
  • NHE8
  • NHE8
  • NHE-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
histone modification site profile
0.9
kinase perturbation
0.81
molecular function
0.79
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.33   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.33   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
ZNF268
Tbio
Family:  TF
Novelty:  0.0471762
p_int:  0.999999937
p_ni:  6e-8
p_wrong:  2e-9
Data Source:  BioPlex
ZNF614
Tdark
Family:  TF
Novelty:  2.89995493
p_int:  0.999999884
p_ni:  3e-9
p_wrong:  1.13e-7
Data Source:  BioPlex
ZNF432
Tdark
Family:  TF
Novelty:  1.41470343
p_int:  0.999999559
p_ni:  1.79e-7
p_wrong:  2.61e-7
Score:  0.281
Data Source:  BioPlex,STRINGDB
MINK1
Tchem
Family:  Kinase
Novelty:  0.00505208
p_int:  0.999942469
p_ni:  0.000057522
p_wrong:  9e-9
Data Source:  BioPlex
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999774563
p_ni:  0.000225435
p_wrong:  3e-9
Data Source:  BioPlex
ZNF182
Tbio
Family:  TF
Novelty:  0.08568537
p_int:  0.999697248
p_ni:  5e-9
p_wrong:  0.000302746
Data Source:  BioPlex
ZNF300
Tbio
Family:  TF
Novelty:  0.12087663
p_int:  0.999502024
p_ni:  1.1e-8
p_wrong:  0.000497965
Data Source:  BioPlex
MYH11
Tbio
Novelty:  0.00142474
p_int:  0.997023228
p_ni:  0.000179549
p_wrong:  0.002797223
Data Source:  BioPlex
SPPL3
Tbio
Family:  Enzyme
Novelty:  0.02388781
p_int:  0.955397054
p_ni:  0.0363581
p_wrong:  0.008244846
Data Source:  BioPlex
EPHB4
Tchem
Family:  Kinase
Novelty:  0.00422975
p_int:  0.935069753
p_ni:  0.064888596
p_wrong:  0.000041651
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Proton exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium/Proton exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
73.4
psoriasis vulgaris
1
1
0
1.2
54.4
2
2
0
1.1
17.6
gut microbiome measurement
1
1
1
14.2
1
1
0
2.1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
73.4
psoriasis vulgaris
0
1.2
54.4
0
1.1
17.6
gut microbiome measurement
1
14.2
0
2.1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A8
VGNC:9988
458326
Macaque
solute carrier family 9 member A8
713706
Mouse
MGI:1924281
77031
Rat
RGD:1308193
311651
Dog
solute carrier family 9 member A8
VGNC:46490
611370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A8
Macaque
solute carrier family 9 member A8
Mouse
Rat
Dog
solute carrier family 9 member A8
Publication Statistics
PubMed Score 39.33
PubMed score by year
PubTator Score 16.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title