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Tbio
SLC9A6
Sodium/hydrogen exchanger 6

Protein Summary
Description
Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370695
  • ENSP00000359729
  • ENSG00000198689
  • ENST00000370698
  • ENSP00000359732
  • ENST00000370701
  • ENSP00000359735
  • ENST00000636092
  • ENSP00000490406
  • ENST00000636347
  • ENSP00000490648
  • ENST00000637234
  • ENSP00000490527
  • ENST00000637581
  • ENSP00000490731

Symbol
  • KIAA0267
  • NHE6
  • MRSA
  • NHE6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
cellular component
0.87
transcription factor perturbation
0.84
histone modification site profile
0.82
tissue sample
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.92   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.92   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0