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Tbio
SLC9A3R2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Protein Summary
Description
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424542
  • ENSP00000408005
  • ENSG00000065054
  • ENST00000432365
  • ENSP00000402857
  • ENST00000566198
  • ENSP00000456895

Symbol
  • NHERF2
  • SIP1
  • OCTS2
  • SIP-1
  • TKA-1
  • E3KARP
  • NHERF2
  • NHE3RF2
  • NHERF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
cell type or tissue
0.83
gene perturbation
0.75
cellular component
0.64
small molecule perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.49   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.49   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
PLCB3
Tbio
Family:  Enzyme
Novelty:  0.01388454
p_int:  1
Score:  0.951
Data Source:  BioPlex,STRINGDB
ARHGAP17
Tbio
Family:  Enzyme
Novelty:  0.06611987
p_int:  0.999999994
p_ni:  6e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
PHLPP2
Tbio
Family:  Enzyme
Novelty:  0.02479769
p_int:  0.999999978
p_ni:  2.2e-8
Score:  0.581
Data Source:  BioPlex,STRINGDB
TBC1D10A
Tbio
Novelty:  0.16930827
p_int:  0.999999961
p_ni:  3.9e-8
Score:  0.66
Data Source:  BioPlex,STRINGDB
SMARCAL1
Tbio
Novelty:  0.01436868
p_int:  0.999999835
p_ni:  1.65e-7
Data Source:  BioPlex
YAP1
Tchem
Novelty:  0.00124225
p_int:  0.999999817
p_ni:  1.83e-7
Score:  0.583
Data Source:  BioPlex,STRINGDB
KCTD2
Tdark
Novelty:  0.42992811
p_int:  0.999998269
p_ni:  0.000001727
p_wrong:  4e-9
Data Source:  BioPlex
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
p_int:  0.999997753
p_ni:  0.000002247
Data Source:  BioPlex
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.999991394
p_ni:  0.000008605
p_wrong:  1e-9
Score:  0.873
Data Source:  BioPlex,STRINGDB
ARHGAP44
Tbio
Family:  Enzyme
Novelty:  0.11113234
p_int:  0.999991321
p_ni:  0.000008679
Score:  0.216
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
3
82.9
appendicular lean mass
3
1
3
81.2
serum gamma-glutamyl transferase measurement
1
1
1
81
BMI-adjusted waist circumference
2
3
4
80.2
2
3
0
1.1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
82.9
appendicular lean mass
3
81.2
serum gamma-glutamyl transferase measurement
1
81
BMI-adjusted waist circumference
4
80.2
0
1.1
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SLC9A3 regulator 2
694658
Mouse
MGI:1890662
65962
Rat
RGD:620380
116501
Dog
SLC9A3 regulator 2
VGNC:46486
479884
Horse
SLC9A3 regulator 2
VGNC:51242
100146142
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SLC9A3 regulator 2
Mouse
Rat
Dog
SLC9A3 regulator 2
Horse
SLC9A3 regulator 2
Publication Statistics
PubMed Score 64.49
PubMed score by year
PubTator Score 58.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title