Tchem SLC9A3R2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Protein Summary

Description

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q15599
• D3DU84
• D3DU85
• H3BSV6
• O00272
• O00556
• Q3KQY7
• NHERF-2

Gene Name

• SLC9A3R2

Ensembl ID

• ENST00000424542
• ENSP00000408005
• ENSG00000065054
• ENST00000432365
• ENSP00000402857
• ENST00000566198
• ENSP00000456895

Symbol

• NHERF2
• SIP1
• OCTS2
• SIP-1
• TKA-1
• E3KARP
• NHERF2
• NHE3RF2
• NHERF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
cell type or tissue	0.83
gene perturbation	0.75
cellular component	0.64
small molecule perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.24   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 235   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.24   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0