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Tchem
SLC8A3
Sodium/calcium exchanger 3

Protein Summary
Description
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216568
  • ENSP00000216568
  • ENSG00000100678
  • ENST00000356921
  • ENSP00000349392
  • ENST00000357887
  • ENSP00000350560
  • ENST00000381269
  • ENSP00000370669
  • ENST00000394330
  • ENSP00000377863
  • ENST00000494208
  • ENSP00000436332
  • ENST00000528359
  • ENSP00000433531
  • ENST00000534137
  • ENSP00000436688

Symbol
  • NCX3
  • NCX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.95
molecular function
0.79
transcription factor
0.76
biological process
0.67
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.46   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.46   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0