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Tchem
SLC8A3
Sodium/calcium exchanger 3

Protein Summary
Description
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216568
  • ENSP00000216568
  • ENSG00000100678
  • ENST00000356921
  • ENSP00000349392
  • ENST00000357887
  • ENSP00000350560
  • ENST00000381269
  • ENSP00000370669
  • ENST00000394330
  • ENSP00000377863
  • ENST00000494208
  • ENSP00000436332
  • ENST00000528359
  • ENSP00000433531
  • ENST00000534137
  • ENSP00000436688

Symbol
  • NCX3
  • NCX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.95
molecular function
0.79
transcription factor
0.76
biological process
0.67
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.79   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.79   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (47)
GPD2
Tbio
Family:  Enzyme
Novelty:  0.00951917
p_int:  0.992746129
p_ni:  0.007253871
Score:  0.204
Data Source:  BioPlex,STRINGDB
REEP4
Tbio
Novelty:  0.37950931
p_int:  0.977915709
p_ni:  0.020403502
p_wrong:  0.001680789
Score:  0.207
Data Source:  BioPlex,STRINGDB
SLC8A2
Tbio
Family:  Transporter
Novelty:  0.01423879
p_int:  0.977449547
p_ni:  2e-9
p_wrong:  0.022550451
Score:  0.941
Data Source:  BioPlex,STRINGDB
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.892023963
p_ni:  0.107976037
Score:  0.171
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.867086303
p_ni:  0.132912998
p_wrong:  6.99e-7
Data Source:  BioPlex
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
Score:  0.917
Data Source:  Reactome,STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.804
Data Source:  STRINGDB
SLC8A1
Tchem
Family:  Transporter
Novelty:  0.0023933
Score:  0.804
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.804
Data Source:  STRINGDB
SLC8B1
Tbio
Family:  Transporter
Novelty:  0.01803421
Score:  0.73
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion homeostasis
Reactome
Mitochondrial calcium ion transport
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion homeostasis
Mitochondrial calcium ion transport
Muscle contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
1
1
0
2.2
57.3
heel bone mineral density
1
1
1
36.5
1
1
0
7.1
4.3
1
1
0
1.1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
0
2.2
57.3
heel bone mineral density
1
36.5
0
7.1
4.3
0
1.1
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member A3
VGNC:8214
467491
Macaque
solute carrier family 8 member A3
713061
Mouse
MGI:107976
110893
Rat
RGD:620197
140448
Dog
solute carrier family 8 member A3
VGNC:46482
490755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member A3
Macaque
solute carrier family 8 member A3
Mouse
Rat
Dog
solute carrier family 8 member A3
Publication Statistics
PubMed Score 101.79
PubMed score by year
PubTator Score 41.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title