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Tbio
SLC8A2
Sodium/calcium exchanger 2

Protein Summary
Description
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236877
  • ENSP00000236877
  • ENSG00000118160

Symbol
  • KIAA1087
  • NCX2
  • NCX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
microRNA
0.69
cell line
0.55
cell type or tissue
0.5
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.05   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.05   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
SLC8A3
Tchem
Family:  Transporter
Novelty:  0.01041945
p_int:  0.977449547
p_ni:  2e-9
p_wrong:  0.022550451
Score:  0.941
Data Source:  BioPlex,STRINGDB
SLC8A1
Tchem
Family:  Transporter
Novelty:  0.0023933
Score:  0.813
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.807
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.804
Data Source:  STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
Score:  0.786
Data Source:  STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
Score:  0.726
Data Source:  STRINGDB
SLC8B1
Tbio
Family:  Transporter
Novelty:  0.01803421
Score:  0.722
Data Source:  STRINGDB
ATP2B1
Tbio
Family:  Transporter
Novelty:  0.00706808
Score:  0.614
Data Source:  STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
Score:  0.613
Data Source:  STRINGDB
CAPN15
Tbio
Novelty:  0.01046841
Score:  0.59
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Platelet calcium homeostasis
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion homeostasis
Muscle contraction
Platelet calcium homeostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.6
57.8
gait measurement
1
1
1
21.5
gut microbiome measurement
1
1
0
5.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.6
57.8
gait measurement
1
21.5
gut microbiome measurement
0
5.5
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member A2
VGNC:12110
468932
Mouse
MGI:107996
110891
Rat
RGD:620194
140447
Dog
solute carrier family 8 member A2
VGNC:46481
484420
Cow
solute carrier family 8 member A2
VGNC:34936
535881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member A2
Mouse
Rat
Dog
solute carrier family 8 member A2
Cow
solute carrier family 8 member A2
Publication Statistics
PubMed Score 64.05
PubMed score by year
PubTator Score 29.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title