SLC8A2
Sodium/calcium exchanger 2
Protein Summary
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.
- ENST00000236877
- ENSP00000236877
- ENSG00000118160
- KIAA1087
- NCX2
- NCX2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.79 | ||
microRNA | 0.69 | ||
cell line | 0.55 | ||
cell type or tissue | 0.5 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.05 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 70 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.05 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 70 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
SLC8A3
Family: Transporter
Novelty: 0.01041945
p_int: 0.977449547
p_ni: 2e-9
p_wrong: 0.022550451
Score: 0.941
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (23)
Reactome (11)
KEGG (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Hemostasis | ||||
Reactome | Ion homeostasis | ||||
Reactome | Muscle contraction | ||||
Reactome | Platelet calcium homeostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Hemostasis | ||||
Ion homeostasis | ||||
Muscle contraction | ||||
Platelet calcium homeostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (5)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 2.6 | 57.8 | |||||
gait measurement | 1 | 1 | 1 | 21.5 | |||||
gut microbiome measurement | 1 | 1 | 0 | 5.5 | 15.8 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 2.6 | 57.8 | |||||
gait measurement | 1 | 21.5 | |||||
gut microbiome measurement | 0 | 5.5 | 15.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 8 member A2 | VGNC:12110 | 468932 | |||||
Mouse | MGI:107996 | 110891 | ||||||
Rat | RGD:620194 | 140447 | ||||||
Dog | solute carrier family 8 member A2 | VGNC:46481 | 484420 | |||||
Cow | solute carrier family 8 member A2 | VGNC:34936 | 535881 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 8 member A2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 8 member A2 | |||||
Cow | solute carrier family 8 member A2 | |||||
Publication Statistics
PubMed Score 64.05
PubMed score by year
PubTator Score 29.30
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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