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Tchem
SLC8A1
Sodium/calcium exchanger 1

Protein Summary
Description
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332839
  • ENSP00000332931
  • ENSG00000183023
  • ENST00000402441
  • ENSP00000385188
  • ENST00000403092
  • ENSP00000384763
  • ENST00000405269
  • ENSP00000385535
  • ENST00000405901
  • ENSP00000385678
  • ENST00000406391
  • ENSP00000385811
  • ENST00000406785
  • ENSP00000383886
  • ENST00000408028
  • ENSP00000384908

Symbol
  • CNC
  • NCX1
  • NCX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.91
microRNA
0.84
phenotype
0.78
disease
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 442.2   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 442.2   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 294
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (294)
US8912224, 345
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US8912224, 353
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US8912224, 15
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US8912224, 16
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US8912224, 19
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US8912224, 21
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US8912224, 24
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US8912224, 29
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US8912224, 36
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US8912224, 45
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Protein-Protein Interactions (95)
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.901
Data Source:  STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.893
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.825
Data Source:  STRINGDB
SLC8A2
Tbio
Family:  Transporter
Novelty:  0.01423879
Score:  0.813
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.809
Data Source:  STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.808
Data Source:  STRINGDB
ATP2A2
Tchem
Family:  Transporter
Novelty:  0.00133604
Score:  0.806
Data Source:  STRINGDB
SLC8A3
Tchem
Family:  Transporter
Novelty:  0.01041945
Score:  0.804
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.793
Data Source:  STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
Score:  0.774
Data Source:  STRINGDB
Nearest Tclin Targets (10)
Explore Nearest Tclin Targets
1 – 5 of 10
Pathways (28)
Cardiac conduction (R-HSA-5576891)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Platelet calcium homeostasis
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion homeostasis
Muscle contraction
Platelet calcium homeostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (59)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
8
93.7
PR interval
2
2
0
2
72.8
glomerular filtration rate
2
1
2
62.5
QT interval
2
3
0
1.8
62
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
93.7
PR interval
0
2
72.8
glomerular filtration rate
2
62.5
QT interval
0
1.8
62
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member A1
VGNC:7710
470358
Macaque
solute carrier family 8 member A1
574193
Mouse
MGI:107956
20541
Rat
RGD:3717
29715
Dog
solute carrier family 8 member A1
VGNC:46480
475738
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member A1
Macaque
solute carrier family 8 member A1
Mouse
Rat
Dog
solute carrier family 8 member A1
Publication Statistics
PubMed Score 442.20
PubMed score by year
PubTator Score 583.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title