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Tchem
SLC8A1
Sodium/calcium exchanger 1

Protein Summary
Description
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332839
  • ENSP00000332931
  • ENSG00000183023
  • ENST00000402441
  • ENSP00000385188
  • ENST00000403092
  • ENSP00000384763
  • ENST00000405269
  • ENSP00000385535
  • ENST00000405901
  • ENSP00000385678
  • ENST00000406391
  • ENSP00000385811
  • ENST00000406785
  • ENSP00000383886
  • ENST00000408028
  • ENSP00000384908

Symbol
  • CNC
  • NCX1
  • NCX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.91
microRNA
0.84
phenotype
0.78
disease
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.23   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.23   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 294
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0