Tbio SLC7A8 Large neutral amino acids transporter small subunit 2

Protein Summary

Description

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.

Uniprot Accession IDs

• Q9UHI5
• B2R8Q4
• B4DKT4
• B4DTV6
• D3DS46
• F2Z2J4
• Q86U05
• Q9UKQ6
• Q9UKQ7
• Q9UKQ8
• Q9Y445

Gene Name

• SLC7A8

Ensembl ID

• ENST00000316902
• ENSP00000320378
• ENSG00000092068
• ENST00000422941
• ENSP00000416398
• ENST00000453702
• ENSP00000391577
• ENST00000529705
• ENSP00000434345

Symbol

• LAT2
• LAT2
• LPI-PC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.9
PubMedID	0.86
molecular function	0.76
small molecule perturbation	0.7
kinase perturbation	0.66

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc3 And Slc7 Families Of Heteromeric Amino Acid Transporters (Hats) / Slc7 Family / Large Neutral Amino Acids Transporter Small Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.54   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.54   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0