SLC6A9
Sodium- and chloride-dependent glycine transporter 1
Protein Summary
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
- ENST00000357730
- ENSP00000350362
- ENSG00000196517
- ENST00000360584
- ENSP00000353791
- ENST00000372310
- ENSP00000361384
- GLYT1
- GCENSG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
molecular function | 0.95 | ||
gene perturbation | 0.85 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.62 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.62 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 834
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0