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Tchem
SLC6A9
Sodium- and chloride-dependent glycine transporter 1

Protein Summary
Description
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357730
  • ENSP00000350362
  • ENSG00000196517
  • ENST00000360584
  • ENSP00000353791
  • ENST00000372310
  • ENSP00000361384

Symbol
  • GLYT1
  • GCENSG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.95
gene perturbation
0.85
kinase perturbation
0.81
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 834
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (834)
CHEMBL394236
Rendered image for CHEMBL394236
CHEMBL597032
Rendered image for CHEMBL597032
CHEMBL239605
Rendered image for CHEMBL239605
CHEMBL239603
Rendered image for CHEMBL239603
CHEMBL239601
Rendered image for CHEMBL239601
CHEMBL393168
Rendered image for CHEMBL393168
CHEMBL403515
Rendered image for CHEMBL403515
CHEMBL392350
Rendered image for CHEMBL392350
CHEMBL239596
Rendered image for CHEMBL239596
bitopertin
Rendered image for bitopertin
Protein-Protein Interactions (40)
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.997220021
p_ni:  2.17e-7
p_wrong:  0.002779762
Score:  0.188
Data Source:  BioPlex,STRINGDB
HMGN3
Tbio
Novelty:  0.07122671
Score:  0.979
Data Source:  STRINGDB
GLRA3
Tchem
Family:  IC
Novelty:  0.0209653
Score:  0.755
Data Source:  STRINGDB
GLRA4
Tdark
Family:  IC
Novelty:  0.07586108
Score:  0.755
Data Source:  STRINGDB
SLC22A14
Tdark
Family:  Transporter
Novelty:  0.3340737
Score:  0.709
Data Source:  STRINGDB
SLC32A1
Tchem
Family:  Transporter
Novelty:  0.00237273
Score:  0.672
Data Source:  STRINGDB
CCDC24
Tdark
Novelty:  1.61025655
Score:  0.669
Data Source:  STRINGDB
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
Score:  0.665
Data Source:  STRINGDB
GLRA1
Tclin
Family:  IC
Novelty:  0.00565137
Score:  0.655
Data Source:  STRINGDB
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
Score:  0.65
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Na+/Cl- dependent neurotransmitter transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
6
80.5
intelligence
3
3
2
5.8
72.6
cognitive function measurement
3
2
3
66.3
household income
1
2
2
60.8
2
1
1
1.1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
6
80.5
intelligence
2
5.8
72.6
cognitive function measurement
3
66.3
household income
2
60.8
1
1.1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 9
VGNC:8116
456520
Macaque
solute carrier family 6 member 9
702346
Mouse
MGI:95760
14664
Rat
RGD:621243
116509
Dog
solute carrier family 6 member 9
VGNC:46469
482526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 9
Macaque
solute carrier family 6 member 9
Mouse
Rat
Dog
solute carrier family 6 member 9
Publication Statistics
PubMed Score 20.21
PubMed score by year
PubTator Score 158.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title