SLC6A8
Sodium- and chloride-dependent creatine transporter 1
Protein Summary
Required for the uptake of creatine in muscles and brain. The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- ENST00000253122
- ENSP00000253122
- ENSG00000130821
- ENST00000430077
- ENSP00000403041
- CRT
- CT1
- CRTR
- CTR5
- CCDS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
molecular function | 0.91 | ||
PubMedID | 0.88 | ||
disease perturbation | 0.83 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 375.68 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 375.68 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0