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Tbio
SLC6A6
Sodium- and chloride-dependent taurine transporter

Protein Summary
Description
Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621751
  • ENSP00000482560
  • ENSG00000131389
  • ENST00000622186
  • ENSP00000480890

Symbol
  • TAUT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.95
kinase perturbation
0.93
molecular function
0.86
cell type or tissue
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.08   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.08   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
PDZK1P1
Tdark
p_int:  0.999996317
p_ni:  0.000003682
p_wrong:  1e-9
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999943123
p_ni:  0.000053486
p_wrong:  0.00000339
Data Source:  BioPlex
NMUR2
Tchem
Family:  GPCR
Novelty:  0.01353039
p_int:  0.998729634
p_ni:  0.00035702
p_wrong:  0.000913346
Score:  0.216
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.998499778
p_ni:  0.000331699
p_wrong:  0.001168522
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.998041375
p_ni:  0.000296961
p_wrong:  0.001661664
Score:  0.162
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.989454479
p_ni:  0.007197746
p_wrong:  0.003347775
Score:  0.186
Data Source:  BioPlex,STRINGDB
NFAT5
Tbio
Family:  TF
Novelty:  0.00452046
Score:  0.802
Data Source:  STRINGDB
CSAD
Tbio
Family:  Enzyme
Novelty:  0.01293688
Score:  0.73
Data Source:  STRINGDB
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
Score:  0.659
Data Source:  STRINGDB
SLC25A33
Tbio
Family:  Transporter
Novelty:  0.17554778
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (66)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of inorganic cations/anions and amino acids/oligopeptides
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
77.9
mean platelet volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
77.9
mean platelet volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 6 member 6
701172
Mouse
MGI:98488
21366
Rat
RGD:61912
29464
Dog
solute carrier family 6 member 6
VGNC:46467
404000
Horse
solute carrier family 6 member 6
100055795
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 6 member 6
Mouse
Rat
Dog
solute carrier family 6 member 6
Horse
solute carrier family 6 member 6
Publication Statistics
PubMed Score 328.08
PubMed score by year
PubTator Score 83.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title