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Tchem
SLC6A5
Sodium- and chloride-dependent glycine transporter 2

Protein Summary
Description
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000525748
  • ENSP00000434364
  • ENSG00000165970

Symbol
  • GLYT2
  • NET1
  • NET1
  • GLYT2
  • HKPX3
  • GLYT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
cell type or tissue
0.74
cell line
0.61
PubMedID
0.56
transcription factor
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.44   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.44   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (89)
CHEMBL394236
Rendered image for CHEMBL394236
CHEMBL239605
Rendered image for CHEMBL239605
CHEMBL239603
Rendered image for CHEMBL239603
CHEMBL239601
Rendered image for CHEMBL239601
CHEMBL393168
Rendered image for CHEMBL393168
CHEMBL392350
Rendered image for CHEMBL392350
bitopertin
Rendered image for bitopertin
CHEMBL524135
Rendered image for CHEMBL524135
Org 25543
Rendered image for Org 25543
CHEMBL3325502
Rendered image for CHEMBL3325502
Protein-Protein Interactions (57)
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.99535307
p_ni:  0.00464693
Data Source:  BioPlex
GPR89A
Tbio
Family:  IC
Novelty:  0.06782776
p_int:  0.974172872
p_ni:  0.025822007
p_wrong:  0.000005121
Data Source:  BioPlex
TBC1D24
Tbio
Novelty:  0.0161631
p_int:  0.965425722
p_ni:  0.031052098
p_wrong:  0.00352218
Score:  0.226
Data Source:  BioPlex,STRINGDB
ARL6IP5
Tbio
Novelty:  0.00871985
p_int:  0.928759477
p_ni:  0.071240523
Score:  0.313
Data Source:  BioPlex,STRINGDB
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.919084625
p_ni:  0.043788259
p_wrong:  0.037127116
Score:  0.547
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.918512275
p_ni:  0.081487725
Score:  0.55
Data Source:  BioPlex,STRINGDB
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.853853249
p_ni:  0.146146751
Data Source:  BioPlex
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.817207554
p_ni:  0.182792446
Score:  0.243
Data Source:  BioPlex,STRINGDB
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.781170301
p_ni:  0.218829683
p_wrong:  1.7e-8
Score:  0.656
Data Source:  BioPlex,STRINGDB
NAT14
Tbio
Family:  Enzyme
Novelty:  0.08842982
p_int:  0.760528253
p_ni:  0.239471743
p_wrong:  4e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) (R-HSA-5619089)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
SLC transporter disorders
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
1
2
77.9
educational attainment
1
1
1
35.6
carotid artery intima media thickness
1
1
1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
77.9
educational attainment
1
35.6
carotid artery intima media thickness
1
7.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 5
VGNC:7745
466470
Macaque
solute carrier family 6 member 5
704703
Mouse
MGI:105090
104245
Rat
RGD:621824
171148
Dog
solute carrier family 6 member 5
VGNC:46466
612095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 5
Macaque
solute carrier family 6 member 5
Mouse
Rat
Dog
solute carrier family 6 member 5
Publication Statistics
PubMed Score 302.44
PubMed score by year
PubTator Score 32.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title